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[体外膜肺氧合治疗的适应症与局限性:关于证据、治疗决策及伦理挑战的思考]

[Indications and limitations of ECMO therapy : Considerations on evidence, treatment decisions and ethical challenges].

作者信息

Karagiannidis C, Bein T, Weber-Carstens S

机构信息

ARDS und ECMO Zentrum, Lungenklinik Köln-Merheim, Kliniken der Stadt Köln gGmbH, Universität Witten/Herdecke, Ostmerheimer Straße 200, 51109, Köln, Deutschland.

Klinik für Anästhesie und operative Intensivmedizin, Universitätsklinikum Regensburg, Regensburg, Deutschland.

出版信息

Med Klin Intensivmed Notfmed. 2019 Apr;114(3):207-213. doi: 10.1007/s00063-019-0533-3. Epub 2019 Feb 5.

DOI:10.1007/s00063-019-0533-3
PMID:30721332
Abstract

The present work sheds light on the possibilities and limitations of modern extracorporeal membrane oxygenation (ECMO) therapy in the case of heart or lung failure. Since the number of applications of extracorporeal lung and heart/lung replacement procedures has increased dramatically in the last few years in severely ill patients, decision-making for a meaningful indication and in the course of a possible therapy target change has become particularly difficult, especially with regard to the complex situation in organ transplantation in Germany. An attempt is made to elucidate the dilemma between data from large controlled trials and epidemiological studies and the patients' individuality.

摘要

目前的研究揭示了现代体外膜肺氧合(ECMO)治疗在心肺衰竭病例中的可能性和局限性。由于过去几年中,重症患者体外肺和心肺替代程序的应用数量急剧增加,对于有意义的适应症的决策以及在可能的治疗目标改变过程中的决策变得尤为困难,特别是考虑到德国器官移植的复杂情况。本文试图阐明大型对照试验和流行病学研究数据与患者个体性之间的困境。

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Med Klin Intensivmed Notfmed. 2019 Apr;114(3):207-213. doi: 10.1007/s00063-019-0533-3. Epub 2019 Feb 5.
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Feasibility, safety, and resource utilisation of active mobilisation of patients on extracorporeal life support: a prospective observational study.

本文引用的文献

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Mechanical Ventilation and Extracorporeal Membrane Oxygena tion in Acute Respiratory Insufficiency.急性呼吸功能不全的机械通气和体外膜肺氧合。
Dtsch Arztebl Int. 2018 Dec 14;115(50):840-847. doi: 10.3238/arztebl.2018.0840.
2
[Organ donation : Update 2019].[器官捐献:2019年更新]
Med Klin Intensivmed Notfmed. 2019 Mar;114(2):100-106. doi: 10.1007/s00063-018-0513-z. Epub 2018 Nov 28.
3
[Evolving Epidemiology of Home Mechanical Ventilation: A Rapidly Growing Challenge for Patient Care].[家庭机械通气不断演变的流行病学:对患者护理的快速增长的挑战]
体外生命支持下患者主动活动的可行性、安全性及资源利用:一项前瞻性观察性研究
Ann Intensive Care. 2020 Dec 1;10(1):161. doi: 10.1186/s13613-020-00776-3.
Dtsch Med Wochenschr. 2019 May;144(9):e58-e63. doi: 10.1055/a-0758-4512. Epub 2018 Nov 21.
4
[EOLIA trial : Does ECMO confer a survival advantage in ARDS?].[体外膜肺氧合试验:体外膜肺氧合在急性呼吸窘迫综合征中是否具有生存优势?]
Med Klin Intensivmed Notfmed. 2019 Mar;114(2):164-165. doi: 10.1007/s00063-018-0511-1. Epub 2018 Nov 12.
5
ECMO for Severe Acute Respiratory Distress Syndrome.用于严重急性呼吸窘迫综合征的体外膜肺氧合
N Engl J Med. 2018 Sep 13;379(11):1091-2. doi: 10.1056/NEJMc1808731.
6
Decline in Organ Donation in Germany.德国器官捐赠数量下降。
Dtsch Arztebl Int. 2018 Jul 9;115(27-28):463-468. doi: 10.3238/arztebl.2018.0463.
7
Evolution of Left Ventricular Assist Device Therapy for Advanced Heart Failure: A Review.左心室辅助装置治疗晚期心力衰竭的演变:综述。
JAMA Cardiol. 2018 Jul 1;3(7):650-658. doi: 10.1001/jamacardio.2018.0522.
8
Quality of life and life satisfaction are severely impaired in patients with long-term invasive ventilation following ICU treatment and unsuccessful weaning.在重症监护病房(ICU)治疗后长期进行有创通气且撤机失败的患者中,生活质量和生活满意度严重受损。
Ann Intensive Care. 2018 Mar 16;8(1):38. doi: 10.1186/s13613-018-0384-8.
9
Indications for extracorporeal support: why do we need the results of the EOLIA trial?体外支持的适应症:我们为何需要EOLIA试验的结果?
Med Klin Intensivmed Notfmed. 2018 Feb;113(Suppl 1):21-25. doi: 10.1007/s00063-017-0371-0. Epub 2017 Nov 17.
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Efficacy of extracorporeal cardiopulmonary resuscitation compared to conventional cardiopulmonary resuscitation for adult cardiac arrest patients: a systematic review and meta-analysis.体外心肺复苏与传统心肺复苏对成年心脏骤停患者的疗效比较:一项系统评价和荟萃分析。
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