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Clinical pharmacokinetics of doxycycline and minocycline.

作者信息

Saivin S, Houin G

机构信息

Unité de Pharmacocinétique Clinique, CHU Purpan, Toulouse, France.

出版信息

Clin Pharmacokinet. 1988 Dec;15(6):355-66. doi: 10.2165/00003088-198815060-00001.

DOI:10.2165/00003088-198815060-00001
PMID:3072140
Abstract

Doxycycline and minocycline are second-generation tetracyclines. They are readily absorbed, distributed throughout the organism as a function of their lipophilicity and eliminated in both the urine and the faeces. The influence of age, renal disease, malnutrition and hyperlipidaemia is reviewed, together with the main pharmacokinetic interactions.

摘要

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本文引用的文献

1
Serum minocycline kinetics in children.
Indian J Med Res. 1980 May;71:764-7.
2
Pharmacokinetics of doxycycline reabsorption.
J Pharm Sci. 1980 Feb;69(2):204-7. doi: 10.1002/jps.2600690224.
3
[Use of tetracyclines during renal failure].[肾衰竭期间四环素类药物的使用]
Nouv Presse Med. 1980 Jan 10;9(21 Suppl):86-92.
4
[Hemo-synovial diffusion of doxycycline in patients with joint effusion].
米诺环素相关的药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征的临床表现、诊断标准及治疗结果：已发表病例的综合探究
Front Pharmacol. 2025 Jul 22;16:1515000. doi: 10.3389/fphar.2025.1515000. eCollection 2025.
4
treatment strategies: a review of therapeutic challenges and considerations.治疗策略：治疗挑战与考量综述
Antimicrob Agents Chemother. 2025 Aug 6;69(8):e0106324. doi: 10.1128/aac.01063-24. Epub 2025 Jul 9.
5
Pulmonary Infections: Therapeutic Obstacles and Progress in Drug Development.肺部感染：治疗障碍与药物研发进展
Pharmaceuticals (Basel). 2025 Jun 13;18(6):891. doi: 10.3390/ph18060891.
6
In Vitro Activity of Imipenem/Relebactam Alone and in Combination Against Cystic Fibrosis Isolates of .亚胺培南/瑞来巴坦单独及联合使用对囊性纤维化分离株的体外活性 。 你提供的原文似乎不完整，句末“. ”后面应该还有具体内容。
Antibiotics (Basel). 2025 May 10;14(5):486. doi: 10.3390/antibiotics14050486.
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Doxycycline: An essential tool for Alzheimer's disease.强力霉素：治疗阿尔茨海默病的重要工具。
Biomed Pharmacother. 2025 Jul;188:118159. doi: 10.1016/j.biopha.2025.118159. Epub 2025 May 13.
8
Population pharmacokinetic model of oral minocycline in critically ill adult patients with ventilator-associated pneumonia.重症成年呼吸机相关性肺炎患者口服米诺环素的群体药代动力学模型
J Antimicrob Chemother. 2025 May 2;80(5):1420-1426. doi: 10.1093/jac/dkaf090.
9
Increased usage of doxycycline for young children with Lyme disease.多西环素在患莱姆病幼儿中的使用增加。
Front Antibiot. 2024 May 21;3:1388039. doi: 10.3389/frabi.2024.1388039. eCollection 2024.
10
Generalized type II minocycline-induced pigmentation: A case report.全身性II型米诺环素诱导的色素沉着：一例报告。
SAGE Open Med Case Rep. 2024 Nov 19;12:2050313X241297214. doi: 10.1177/2050313X241297214. eCollection 2024.
Nouv Presse Med. 1980 Jan 10;9(21 Suppl):84-5.
5
[Use of doxycycline in human renal failure].
Nouv Presse Med. 1980 Jan 10;9(21 Suppl):82-3.
6
[Pharmacokinetic study of doxycycline in man by high performance liquid chromatography. Administration of single 200 mg doses intravenously and orally].
Nouv Presse Med. 1980 Jan 10;9(21 Suppl):77-81.
7
[Tissue pharmacokinetics of doxycycline compared with those of other antibiotics in rats].
Nouv Presse Med. 1980 Jan 10;9(21 Suppl):71-6.
8
[Structure-activity correlations in the tetracycline family].[四环素家族中的构效关系]
Nouv Presse Med. 1980 Jan 10;9(21 Suppl):64-70.
9
[Passage of doxycycline across the blood-brain barrier].
Nouv Presse Med. 1980 Jan 10;9(21 Suppl):136-7.
10
[Level of doxycycline in the palatine tonsils in the maxillary sinus mucosa and in sinus secretions].[多西环素在上颌窦黏膜、腭扁桃体及鼻窦分泌物中的水平]
Nouv Presse Med. 1980 Jan 10;9(21 Suppl):131-4.