Zhang Jinduo, Su Gang, Lin Yanyan, Meng Wenbo, Lai Jonathan King Lam, Qiao Liang, Li Xun, Xie Xiaodong
Special Minimally Invasive Surgery Department, The First Hospital of Lanzhou University, Lanzhou 730000, China.
Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
Discov Med. 2019 Jan;27(146):27-36.
Cyclin-dependent kinases (CDKs) play an important role in cell-cycle progression. CDKs are positively modulated by regulatory mitotic cyclins and negatively controlled by endogenous CDK inhibitors (CDKIs) cyclically as cells progress through different cell cycles of transitions. When activated by cyclins, cyclin-CDK complexes were able to facilitate the transition of cell cycle from one phase to the next, e.g., from G1 to S or from G2 to M. DNA damages may cause inhibition of CDKs leading to cell-cycle arrest, while unrepairable DNA damage causes cells to undergo apoptosis. Disruption of cell cycle progression is an important cancer hallmark to mediate uncontrolled cell proliferation, tumorigenesis, and metastasis. Aberrantly expressed CDKs are causally linked to the development of gastrointestinal cancers, and as such, CDKs may not only form a class of potential biomarkers for the diagnosis and therapy of gastrointestinal cancers. In this review article, we summarized the data from translational studies using CDKs as a target for gastrointestinal cancer treatment.
细胞周期蛋白依赖性激酶（CDKs）在细胞周期进程中发挥着重要作用。随着细胞经历不同的细胞周期转换，CDKs受到有丝分裂调节性细胞周期蛋白的正向调节，并受到内源性CDK抑制剂（CDKIs）的周期性负向控制。当被细胞周期蛋白激活时，细胞周期蛋白-CDK复合物能够促进细胞周期从一个阶段过渡到下一个阶段，例如从G1期到S期或从G2期到M期。DNA损伤可能导致CDKs受到抑制，从而导致细胞周期停滞，而无法修复的DNA损伤则会导致细胞凋亡。细胞周期进程的破坏是介导不受控制的细胞增殖、肿瘤发生和转移的重要癌症标志。异常表达的CDKs与胃肠道癌症的发生存在因果关系，因此，CDKs不仅可能构成一类用于胃肠道癌症诊断和治疗的潜在生物标志物。在这篇综述文章中，我们总结了以CDKs为靶点进行胃肠道癌症治疗的转化研究数据。
