Cancer Discov. 2019 Mar;9(3):314. doi: 10.1158/2159-8290.CD-NB2019-012. Epub 2019 Feb 5.
A genomic analysis of 8,006 tumors spanning 19 cancer types suggests that hypoxic tumors share common features, including genomic instability. Eleven types of cancer carried extra copies of MYC, and seven types had lost PTEN. The study also found that miRNA dysregulation was prevalent across tumor types.
对 8006 个跨越 19 种癌症类型的肿瘤进行基因组分析表明，缺氧肿瘤具有共同特征，包括基因组不稳定性。11 种癌症类型的 MYC 存在额外拷贝，7 种癌症类型失去了 PTEN。该研究还发现，miRNA 失调在肿瘤类型中普遍存在。
