Carman and Ann Department of Pediatrics, Department of Pediatrics, Hutzel Women's Hospital, 3980 John R Rd, Detroit, MI, 48201, USA.
Department of Pharmacy, Wayne State University, Detroit, MI, 48201, USA.
J Perinatol. 2019 Apr;39(4):540-546. doi: 10.1038/s41372-019-0328-7. Epub 2019 Feb 5.
To evaluate the effect of withholding feeds during transfusion on transfusion associated acute gut injury (TRAGI).
Data were collected on 125 preterm infants before and after the practice of withholding feeds for 12-24 h during transfusion was instituted. Logistic regression was used to examine effects of withholding feeds on TRAGI rates.
A total of 19 (15%) infants developed NEC; 6/19 (32%) had TRAGI. Postnatal hydrocortisone use was associated with TRAGI (OR 8.97; 95% CI 1.17-68.46, p = 0.034). There was no difference in NEC rates (15.8 vs. 14.7%) and the proportions (22.2 vs. 40%) of TRAGI in the two time periods before and after instituting the standardized feeding regimen and practice of holding feeds during transfusion.
No significant decrease was noted in the rates of TRAGI after feeds were withheld during transfusion. Further studies are warranted to explore the relationship between feeds during transfusion and NEC.
评估在输血过程中禁食对输血相关急性肠道损伤（TRAGI）的影响。
在开始实行输血期间禁食 12-24 小时的实践前后，收集了 125 名早产儿的数据。使用逻辑回归来检查禁食对 TRAGI 发生率的影响。
共有 19 名（15%）婴儿发生 NEC；6/19（32%）发生 TRAGI。出生后使用氢化可的松与 TRAGI 相关（OR 8.97；95%CI 1.17-68.46，p=0.034）。在实施标准化喂养方案和在输血过程中禁食的前后两个时间段，NEC 发生率（15.8%与 14.7%）和 TRAGI 比例（22.2%与 40%）无差异。
在输血过程中禁食后，TRAGI 的发生率没有明显下降。需要进一步研究来探讨输血过程中喂养与 NEC 之间的关系。
