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1
Less is more when it comes to ketorolac for pain.在使用酮咯酸止痛方面，少即是多。
J Fam Pract. 2019 Jan/Feb;68(1):41-42.
2
In patients in the emergency department with acute pain, 10, 15, and 30 mg of ketorolac did not differ for pain relief.在急诊科有急性疼痛的患者中，10毫克、15毫克和30毫克的酮咯酸在缓解疼痛方面并无差异。
Ann Intern Med. 2017 Apr 18;166(8):JC44. doi: 10.7326/ACPJC-2017-166-8-044.
3
Comparison of ketorolac dosing in an emergency department setting.
CJEM. 2018 Oct;20(S2):S74-S77. doi: 10.1017/cem.2017.431. Epub 2018 Feb 8.
4
No Added Benefit with Higher Doses of Ketorolac for Treatment of Acute Pain in the Emergency Department.急诊科使用更高剂量酮咯酸治疗急性疼痛无额外获益。
Am Fam Physician. 2017 Aug 15;96(4):262.
5
Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial.三种单次静脉注射剂量的酮咯酸治疗急诊科急性疼痛的比较：一项随机对照试验。
Ann Emerg Med. 2017 Aug;70(2):177-184. doi: 10.1016/j.annemergmed.2016.10.014. Epub 2016 Dec 16.
6
Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department.在急诊科，对乙酰氨基酚-可待因与酮咯酸用于疼痛控制的比较。
Eur Rev Med Pharmacol Sci. 2014 Oct;18(20):3139-43.
7
Usage analysis of ketorolac in the emergency department.急诊科中酮咯酸的使用分析
Am J Emerg Med. 2021 Jul;45:541-542. doi: 10.1016/j.ajem.2020.07.029. Epub 2020 Jul 18.
8
Acute kidney injury during a pediatric sickle cell vaso-occlusive pain crisis.小儿镰状细胞血管阻塞性疼痛危象期间的急性肾损伤
Pediatr Nephrol. 2017 Aug;32(8):1451-1456. doi: 10.1007/s00467-017-3623-6. Epub 2017 Feb 25.
9
NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac.非甾体抗炎药在急诊科的使用及疗效：口服布洛芬单剂量与肌肉注射酮咯酸的对比
Ann Pharmacother. 1994 Mar;28(3):309-12. doi: 10.1177/106002809402800301.
10
Ketorolac dose-response for acute pain is well known and the safety rules for adequate prescribing are clear.酮咯酸对急性疼痛的剂量反应是众所周知的，并且适当开药的安全规则是明确的。
J Clin Anesth. 2018 Feb;44:86. doi: 10.1016/j.jclinane.2017.10.016. Epub 2017 Nov 21.

引用本文的文献

1
Ketorolac Dose Ceiling Effect for Pediatric Headache in the Emergency Department.急诊科小儿头痛的酮咯酸剂量上限效应
J Pediatr Pharmacol Ther. 2024 Oct;29(5):494-500. doi: 10.5863/1551-6776-29.5.494. Epub 2024 Oct 14.

本文引用的文献

1
Patterns of Ketorolac dosing by emergency physicians.急诊医生使用酮咯酸的给药模式。
World J Emerg Med. 2017;8(1):43-46. doi: 10.5847/wjem.j.1920-8642.2017.01.008.
2
Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial.三种单次静脉注射剂量的酮咯酸治疗急诊科急性疼痛的比较：一项随机对照试验。
Ann Emerg Med. 2017 Aug;70(2):177-184. doi: 10.1016/j.annemergmed.2016.10.014. Epub 2016 Dec 16.
3
Risk of hospitalization for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists, and other antihypertensive drugs.与酮咯酸、其他非甾体抗炎药、钙拮抗剂及其他抗高血压药物相关的上消化道出血住院风险。
Arch Intern Med. 1998 Jan 12;158(1):33-9. doi: 10.1001/archinte.158.1.33.
4
The analgesic efficacy of ketorolac for acute pain.
J Emerg Med. 1996 Jan-Feb;14(1):67-75. doi: 10.1016/0736-4679(95)02052-7.
5
Ketorolac. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential.酮咯酸。对其药效学和药代动力学特性以及治疗潜力的综述。
Drugs. 1990 Jan;39(1):86-109. doi: 10.2165/00003495-199039010-00008.

在使用酮咯酸止痛方面，少即是多。

Less is more when it comes to ketorolac for pain.

作者信息

Lyon Corey, Claus Liza W

机构信息

University of Colorado Family Medicine Residency, Denver, CO.

出版信息

J Fam Pract. 2019 Jan/Feb;68(1):41-42.

PMID:30724903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6484969/
Abstract

It's time to review our dosing with ketorolac for acute pain management.

摘要

是时候回顾一下我们使用酮咯酸进行急性疼痛管理的给药方案了。