Department of Gastroenterology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0375, Japan.
Dig Dis Sci. 2019 Jul;64(7):1976-1984. doi: 10.1007/s10620-019-05508-7. Epub 2019 Feb 6.
Endoscopic transmural drainage is performed for symptomatic peripancreatic fluid collections (PPFCs). Long-term transmural double-pigtail stent (DPS) placement is useful in preventing recurrences. There are few reports on the long-term safety of DPS placement. Thus, this study aimed to examine the complications of long-term indwelling DPS for PPFCs.
Among 53 patients who underwent endoscopic ultrasound-guided transmural drainage for symptomatic PPFCs between April 2006 and March 2017, those followed up for over one year were included. Complications of long-term indwelling DPS were examined retrospectively.
This study enrolled 36 patients [30 men, median age 54 years (range 22-82)]. Walled-off necrosis was present in 22 cases (including 9 disconnected pancreatic duct syndrome cases) and pancreatic pseudocysts, in 14 cases. The median stenting period was 20.9 (range 0.8-142.3) months, and median observation period was 56.2 (range 12.4-147.1) months. Colon perforation due to DPS occurred in 3 cases (8.3%), at 5.8, 17.1, and 33.7 months after indwelling DPS placement; 2 cases developed perforation from the serosal side. In 1 case, the patient was treated surgically, and in 2 cases, the patients underwent endoscopic removal of the stent and showed improvement with conservative treatment.
Long-term indwelling transmural DPS for symptomatic PPFCs poses a risk of intestinal perforation. Thus, if possible, it may be better to avoid long-term placement.
内镜经壁引流术用于治疗症状性胰周液体积聚(PPFCs)。长期经壁双猪尾支架(DPS)置入术可有效预防复发。关于 DPS 长期留置的安全性报告较少。因此,本研究旨在探讨长期留置 DPS 治疗 PPFC 的并发症。
在 2006 年 4 月至 2017 年 3 月期间,对 53 例因症状性 PPFC 而行内镜超声引导下经壁引流的患者进行研究,其中对随访时间超过 1 年的患者进行回顾性分析。
本研究纳入 36 例患者(30 例男性,中位年龄 54 岁[范围 22-82 岁])。22 例存在包裹性坏死(包括 9 例胰腺断管综合征),14 例为胰腺假性囊肿。支架置入中位时间为 20.9 个月(范围 0.8-142.3 个月),中位观察时间为 56.2 个月(范围 12.4-147.1 个月)。3 例(8.3%)患者因 DPS 发生结肠穿孔,DPS 留置后 5.8、17.1 和 33.7 个月发生穿孔,2 例从浆膜侧穿孔。1 例患者接受手术治疗,2 例患者行内镜下支架取出术,并经保守治疗后好转。
对症状性胰周液体积聚患者行长期经壁 DPS 留置存在肠穿孔风险,因此,如可能,应尽量避免长期留置。