Hsu Yu-Ming, Lai Wan-Chun, Li Chi-Ying, Lan Yu-Hsuan, Tsai Yu-Chi, Hunyadi Attila, Hou Ming-Feng, Wu Yang-Chang, Chang Fang-Rong
Nat Prod Commun. 2016 Aug;11(8):1099-1102.
Utilizing the pER8:GUS transgenic plant bioassay system to monitor estrogenic activity-guided fractionation, one new constituent, erycaffrain A, together with I known compounds were isolated from the ethanolic extract of Erythrina caffra. The structures of the isolated compounds were identified in combination with spectroscopic analyses. This is the first study reporting the estrogenic activity of E. caffra. The new compound exhibited as a SREM, but.also showed both estrogenic and anti-estrogenic activities in the MCF-7 cancer cell model. Several known phytoestrogens in this plant also revealed possible new functions for E. caffra stem.
利用pER8:GUS转基因植物生物测定系统监测雌激素活性导向的分级分离，从刺桐的乙醇提取物中分离出一种新成分erycaffrain A以及1种已知化合物。通过光谱分析相结合的方法鉴定了分离出的化合物的结构。这是第一项报道刺桐雌激素活性的研究。这种新化合物表现为选择性雌激素受体调节剂（SREM），但在MCF-7癌细胞模型中也显示出雌激素和抗雌激素活性。该植物中的几种已知植物雌激素也揭示了刺桐茎可能的新功能。
