吡喃黑麦角林L，一种由温泉来源的真菌亚当茨青霉BF - 0003产生的新型抗氧化剂。

Pyranonigrin L, a New Antioxidant, Produced by the Hot Spring-derived Fungus Penicillium adametzii BF-0003.

作者信息

Uchida Ryuji, Miyazaki Hidetoshi, Yamaguchi Yuichi, Ishijima Hiroyuki, Tomoda Hiroshi

出版信息

Nat Prod Commun. 2016 Aug;11(8):1111-1114.

Abstract

A new antioxidant, designated pyranonigrin L, was isolated from the culture materials of the hot spring-derived fungus Penicillium adainetzii BF0003 by solvent extraction, ODS column chromatography, and HPLC. Its planar structure was elucidated using various analytical techniques including UV, IR, and NMR spectroscopy and MS. Its absolute configuration was determined by a comparison of its circular dichroism (CD) spectrum with those of structurally related compounds. Pyranonigrin L was found to exhibit anti-oxidative activity with an EC(500 value of 553 μM.

摘要

一种新的抗氧化剂，命名为吡喃黑麦角林L，通过溶剂萃取、ODS柱色谱法和高效液相色谱法从温泉源真菌阿达内齐青霉BF0003的培养物中分离得到。利用包括紫外光谱、红外光谱、核磁共振光谱和质谱在内的各种分析技术阐明了其平面结构。通过将其圆二色性（CD）光谱与结构相关化合物的光谱进行比较，确定了其绝对构型。发现吡喃黑麦角林L具有抗氧化活性，其半数有效浓度（EC₅₀）值为553 μM。