He Haiyin, Bigelis Ramunas, Yang Hui Y, Chang Li-Ping, Singh Maya P
Natural Products Research, Chemical and Screening Sciences, Wyeth 401 N. Middletown Road, Pearl River, NY 10965, USA.
J Antibiot (Tokyo). 2005 Nov;58(11):731-6. doi: 10.1038/ja.2005.99.
Lichenicolous fungus LL-RB0668 was isolated from a processed lichen thallus on a modified Lilly-Barnett solid medium. Two new bisnaphthopyrone compounds, lichenicolins A (1) and B (2), were isolated from the culture broth of this organism fermented on a rice-based solid medium. These results demonstrate that lichen-associated fungi potentially are a good resource for new bioactive natural products for current screening programs.
地衣内生真菌LL-RB0668是从改良的Lilly-Barnett固体培养基上的加工地衣叶状体中分离得到的。从该菌株在大米固体培养基上发酵的培养液中分离出两种新的双萘并吡喃酮化合物，即地衣菌素A（1）和B（2）。这些结果表明，与地衣相关的真菌可能是当前筛选计划中新型生物活性天然产物的良好来源。
