Cristian Cartes, Marco Casas Del Valle, Arturo Kantor, Claudio Pérez, Miguel Srur, Rolf Raimann, Remigio López, Leonidas Traipe
Clínica Universidad de los Andes, Universidad de los Andes, Santiago, Chile.
Fundación Oftalmológica Los Andes, Universidad de los Andes, Santiago, Chile.
Arq Bras Oftalmol. 2019 Mar-Apr;82(2):103-106. doi: 10.5935/0004-2749.20190018. Epub 2019 Jan 10.
To report our initial experience in the treatment of Acanthamoeba keratitis with accelerated corneal collagen cross-linking.
Retrospective chart review of patients diagnosed with Acanthamoeba keratitis with progressive corneal melting who were treated with accelerated collagen cross-linking.
A total of 6 eyes (5 patients) were reviewed. All the patients received adjuvant therapy with moxifloxacin and chlorhexidine. In 4 cases, the ulcer healed with a mean interval to epithelialization of 108.8 days (range 59-217). In 2 eyes, there was a persistent neurotrophic ulcer. The melting was not progressive in any case, nor did any eye required emergency penetrating keratoplasy.
This study suggests a beneficial effect of accelerated collagen cross-linking in cases of Acanthamoeba keratitis with corneal melting. Thus, collagen cross-linking may be considered as adjuvant treatment for Acanthamoeba keratitis.
报告我们使用加速角膜胶原交联治疗棘阿米巴角膜炎的初步经验。
对诊断为棘阿米巴角膜炎且角膜进行性溶解的患者进行回顾性病历审查，这些患者接受了加速胶原交联治疗。
共回顾了6只眼（5例患者）。所有患者均接受了莫西沙星和氯己定辅助治疗。4例患者溃疡愈合，上皮化平均间隔时间为108.8天（范围59 - 217天）。2只眼中存在持续性神经营养性溃疡。在任何情况下角膜溶解均未进展，也没有任何一只眼需要紧急穿透性角膜移植术。
本研究表明加速胶原交联对伴有角膜溶解的棘阿米巴角膜炎病例有有益作用。因此，胶原交联可被视为棘阿米巴角膜炎的辅助治疗方法。
