University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.
University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.
Structure. 2019 Feb 5;27(2):209-210. doi: 10.1016/j.str.2019.01.007.
The cytolytic activity of NK cells is regulated by activating and inhibitory receptors, including ones that recognize cell-cell adhesion molecules. In this issue of Structure, Deuss et al. (2019) report the structure of nectin-like protein-5 bound to the NK inhibitory receptor CD96, a promising new target for cancer immunotherapy.
自然杀伤 (NK) 细胞的细胞溶解活性受激活和抑制性受体的调控，其中包括识别细胞-细胞黏附分子的受体。在本期《结构》杂志中，Deuss 等人（2019 年）报告了连接蛋白样蛋白 5 与 NK 抑制性受体 CD96 结合的结构，CD96 是癌症免疫治疗的一个有前途的新靶点。
