自然杀伤细胞受体如何黏附在细胞-细胞黏附蛋白上。
How Natural Killer Cell Receptors Stick to Cell-Cell Adhesion Proteins.
机构信息
University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.
University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.
出版信息
Structure. 2019 Feb 5;27(2):209-210. doi: 10.1016/j.str.2019.01.007.
PMID:30726753
Abstract
The cytolytic activity of NK cells is regulated by activating and inhibitory receptors, including ones that recognize cell-cell adhesion molecules. In this issue of Structure, Deuss et al. (2019) report the structure of nectin-like protein-5 bound to the NK inhibitory receptor CD96, a promising new target for cancer immunotherapy.
摘要
自然杀伤 (NK) 细胞的细胞溶解活性受激活和抑制性受体的调控，其中包括识别细胞-细胞黏附分子的受体。在本期《结构》杂志中，Deuss 等人（2019 年）报告了连接蛋白样蛋白 5 与 NK 抑制性受体 CD96 结合的结构，CD96 是癌症免疫治疗的一个有前途的新靶点。
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