Department of Occupational Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Department of Family Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Obes Facts. 2019;12(1):67-77. doi: 10.1159/000496626. Epub 2019 Feb 6.
Although obesity is associated with an increased risk of chronic kidney disease, this trend becomes nonsignificant following adjustment for cardiovascular risk factors. The present study aims to investigate whether visceral obesity is independently associated with renal function impairment.
The medical records of 14,529 male and 10,561 female Chinese adults undergoing health check-ups during 2013-2015 were retrospectively collected. The baseline characteristics, including the degree of visceral fat and the percentage of body fat, were compared. The association between study groups and renal function impairment was investigated using regression models adjusted for confounding factors.
All variables differed significantly among non-obese, peripheral, and central type obese subjects, both younger and older, and of both genders, except for hsCRP in older male subjects (p = 0.053) and eGFR in older female subjects (p = 0.098). Unadjusted univariate analysis showed that central obesity contributed significantly to renal function impairment in all age groups and in both genders. After adjusting for possible confounding factors, only central obesity was found to be an independent factor of renal function impairment in all groups, except for men under 45 years of age.
Visceral obesity is independently associated with renal function impairment in all ages and both genders, except for males younger than 45 years.
尽管肥胖与慢性肾脏病风险增加相关，但在调整心血管危险因素后，这种趋势变得无统计学意义。本研究旨在探讨内脏肥胖是否与肾功能损害独立相关。
回顾性收集了 2013-2015 年间进行健康检查的 14529 名男性和 10561 名女性中国成年人的病历。比较了基线特征，包括内脏脂肪程度和体脂百分比。使用回归模型调整混杂因素后，研究组与肾功能损害的相关性。
除了老年男性 hsCRP（p=0.053）和老年女性 eGFR（p=0.098）外，所有变量在非肥胖、外周型和中心型肥胖的年轻和老年、男性和女性受试者之间均有显著差异。未校正的单因素分析表明，中心性肥胖与所有年龄组和所有性别组的肾功能损害显著相关。在调整了可能的混杂因素后，除了 45 岁以下的男性外，只有中心性肥胖被发现是所有组肾功能损害的独立因素。
除了 45 岁以下的男性外，内脏肥胖与所有年龄和性别组的肾功能损害独立相关。
