Jendi Shoeb Kasim, Syed Ahmed M, Badal Sheeraz, Doiphode Amol, Chougule Sandesh S, Shaikh Sameer A, Ahtesham Ahmed
Department of Oral and Maxillofacial Surgery, Yogita Dental College and Hospital, Naringi riverside, Dapoli Road, Khed, Maharashtra India.
Department of Oral and Maxillofacial Surgery, Maharashtra Institute of Dental Sciences and Research Dental College and Hospital, Latur, Maharashtra India.
J Maxillofac Oral Surg. 2019 Mar;18(1):100-105. doi: 10.1007/s12663-018-1104-5. Epub 2018 Mar 27.
Tramadol has been shown to have a local anaesthetic effect when used as infiltration anaesthesia.
The local anaesthetic efficacy of tramadol was compared with that of lignocaine for the extraction of teeth in terms of their onset of action, duration of action, intraoperative pain, post-operative analgesic effect and adverse reactions. Apart from this, incidence of allergic reaction was also recorded for both the drugs. A total of 100 patients were divided into two groups randomly. Each patient was assigned to receive either a maximum of 2 ml of 5% tramadol (Supridol 50 mg, Neon laboratories), Group T ( = 50), as a local anaesthetic solution for extraction of maxillary premolar for orthodontic reason under supraperiosteal infiltration following strict aseptic precaution or a maximum of 2 ml of 2% lignocaine (Lox 2%, Neon laboratories), Group L ( = 50), in a double-blinded fashion.
In group T, the mean subjective onset of action was 33.66 s, while in group L it was 33.06 s ( = 0.881). In group T, the mean objective onset of action was 3.04 min, while in group L it was 3.18 min ( > 0.05). The mean duration of action in group T was 55.60 min, while in group L it was 57.50 min ( = 0.432). Only 2 patients in group T and 1 patient in group L had nausea ( = 0.245).
We conclude that 5% tramadol has a local anaesthetic efficacy similar to 2% lignocaine but is comparatively a weaker agent.
曲马多用作浸润麻醉时已显示出局部麻醉作用。
比较曲马多与利多卡因在拔牙时的局部麻醉效果，包括起效时间、作用持续时间、术中疼痛、术后镇痛效果及不良反应。除此之外，还记录了两种药物的过敏反应发生率。总共100例患者被随机分为两组。在严格的无菌预防措施下，每组患者分别接受最多2毫升5%曲马多（舒普深50毫克，霓虹实验室），T组（n = 50），作为局部麻醉溶液用于因正畸原因拔除上颌前磨牙的骨膜上浸润麻醉，或最多2毫升2%利多卡因（洛克斯2%，霓虹实验室），L组（n = 50），采用双盲方式。
T组主观平均起效时间为33.66秒，而L组为33.06秒（P = 0.881）。T组客观平均起效时间为3.04分钟，而L组为3.18分钟（P>0.05）。T组平均作用持续时间为55.60分钟，而L组为57.50分钟（P = 0.432）。T组仅有2例患者和L组仅有1例患者出现恶心（P = 0.245）。
我们得出结论，5%曲马多具有与2%利多卡因相似的局部麻醉效果，但相对而言是一种较弱的药物。
