抗瓜氨酸化纤维蛋白原抗体在类风湿关节炎中的诊断价值：一项荟萃分析。
Diagnostic value of anti-citrullinated fibrinogen antibody in rheumatoid arthritis: A meta-analysis.
作者信息
Dai Zi-Wei, Wang Zhi-Hui, Dong Yuan-Yuan, Wu Yue, Wang Hai-Li, Wang De-Guang, Wang Bin, Ye Dong-Qing
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, China.
Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
出版信息
Int J Rheum Dis. 2019 Apr;22(4):599-607. doi: 10.1111/1756-185X.13477. Epub 2019 Feb 6.
AIM
To evaluate the overall diagnostic value of anti-citrullinated fibrinogen (ACF) antibody in patients with rheumatoid arthritis (RA).
METHODS
Published studies were systematically retrieved from PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Wan Fang, China Biology Medicine (CBM) disc, and Chinese VIP databases. QUADAS-2 tool was applied to evaluate the quality of eligible studies. Subgroup analysis and meta-regression were used to explore the sources of heterogeneity. Egger's test was used to evaluate for the presence of publication bias.
RESULTS
Seven studies were included in this meta-analysis. The pooled sensitivity, specificity, pooled positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of ACF were 0.61 (95% CI: 0.57-0.64), 0.93 (95% CI: 0.92-0.94), 9.33 (95% CI: 5.15-16.92), 0.39 (95% CI: 0.30-0.53) and 24.58 (95% CI: 11.47-52.64), respectively. The area under the curve was 0.8018. The results of subgroup analysis and meta-regression indicated that the factors we analyzed might not be the leading causes of heterogeneity. No significant publication bias was found.
CONCLUSION
The ACF antibody had a moderate diagnostic accuracy on RA.
目的
评估抗瓜氨酸化纤维蛋白原（ACF）抗体对类风湿关节炎（RA）患者的整体诊断价值。
方法
从PubMed、科学网、中国知网、万方、中国生物医学文献数据库（CBMdisc）和中文维普数据库系统检索已发表的研究。应用QUADAS-2工具评估纳入研究的质量。采用亚组分析和Meta回归探索异质性来源。采用Egger检验评估发表偏倚。
结果
本Meta分析纳入7项研究。ACF的合并敏感度、特异度、合并阳性似然比、阴性似然比及诊断比值比分别为0.61（95%CI：0.57 - 0.64）、0.93（95%CI：0.92 - 0.94）、9.33（95%CI：5.15 - 16.92）、0.39（95%CI：0.30 - 0.53）和24.58（95%CI：11.47 - 52.64）。曲线下面积为0.8018。亚组分析和Meta回归结果表明，所分析的因素可能不是异质性的主要原因。未发现明显的发表偏倚。
结论
ACF抗体对RA具有中等诊断准确性。
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