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青少年膝关节镜检查后出现症状性静脉血栓栓塞症

Symptomatic Venous Thromboembolism After Adolescent Knee Arthroscopy.

作者信息

Murphy Robert F, Heyworth Benton, Kramer Dennis, Naqvi Manahil, Miller Patricia E, Yen Yi-Meng, Kocher Mininder S, Shore Benjamin J

机构信息

Medical University of South Carolina, Charleston, SC and Boston Children's Hospital, Boston, MA.

出版信息

J Pediatr Orthop. 2019 Mar;39(3):125-129. doi: 10.1097/BPO.0000000000000894.

Abstract

BACKGROUND

The frequency of knee arthroscopy procedures is increasing in pediatric and adolescent patients. In general, complications after these procedures in adolescents are uncommon. The purposes of this study are to report the incidence of venous thromboembolism (VTE) in adolescent patients after knee arthroscopy procedures, as well identify risk factors in this patient population.

METHODS

Medical records were reviewed in all pediatric and adolescent patients (≤19 y) who underwent an arthroscopic knee procedure from 2010 to 2014 and were diagnosed with a symptomatic VTE in the postoperative period. Demographic features were recorded, and included age, sex, body mass index, clinical characteristics (diagnosis, type of surgical intervention, tourniquet time), VTE risk factors [family history of VTE, obesity (body mass index >30), oral contraceptive use, and smoking use/exposure] and treatment (anticoagulation type/duration).

RESULTS

Out of 2783 patients who underwent knee arthroscopy during the 5-year study period, 7 patients (3 males, 4 females, mean age, 16.9 y, range, 15 to 18) developed a symptomatic postoperative VTE (incidence, 0.25%, 95% confidence interval, 0.11%-0.54%). There were 6 unilateral deep venous thrombosis, and 1 bilateral deep venous thrombosis. Arthroscopic procedures performed in this cohort included anterior cruciate ligament reconstruction (3), isolated lateral release (1), meniscectomy (2), and patellar realignment with arthroscopic lateral release, open tibial tubercle osteotomy, and open proximal medial retinacular reefing (1). VTE was diagnosed an average of 9 days following surgery (range, 3 to 16). All patients were initially treated with low-molecular-weight heparin, and 2 were converted to warfarin. Mean duration of anticoagulation treatment was 64 days (range, 28 to 183). All patients had at least 1 identifiable medical or surgical risk factor, including oral contraceptive use (2), smoking (2), obesity (2), an arthroscopically assisted open procedure (4), or tourniquet time >60 minutes (3).

CONCLUSIONS

VTE after adolescent knee arthroscopy has not been well described. The incidence is ∼0.25%. Previously established risk factors for VTE were present in 100% of the affected population. Low-molecular-weight heparin was used to successfully treat this complication.

LEVEL OF EVIDENCE

Level IV.

摘要

背景

儿科和青少年患者膝关节镜检查手术的频率正在增加。一般来说,青少年进行这些手术后的并发症并不常见。本研究的目的是报告青少年患者膝关节镜检查手术后静脉血栓栓塞(VTE)的发生率,并确定该患者群体中的风险因素。

方法

回顾了2010年至2014年期间接受膝关节镜手术且术后被诊断为有症状VTE的所有儿科和青少年患者(≤19岁)的病历。记录了人口统计学特征,包括年龄、性别、体重指数、临床特征(诊断、手术干预类型、止血带使用时间)、VTE风险因素[VTE家族史、肥胖(体重指数>30)、口服避孕药使用情况以及吸烟使用/暴露情况]和治疗情况(抗凝类型/持续时间)。

结果

在为期5年的研究期间接受膝关节镜检查的2783例患者中,7例(3例男性,4例女性,平均年龄16.9岁,范围15至18岁)出现了有症状的术后VTE(发生率0.25%,95%置信区间0.11%-0.54%)。有6例单侧深静脉血栓形成,1例双侧深静脉血栓形成。该队列中进行的关节镜手术包括前交叉韧带重建(3例)、单纯外侧松解(1例)、半月板切除术(2例)以及关节镜辅助下外侧松解、开放性胫骨结节截骨术和开放性近端内侧支持带折叠术的髌骨重新排列(1例)。VTE平均在术后9天被诊断(范围3至16天)。所有患者最初均接受低分子量肝素治疗,2例转为华法林治疗。抗凝治疗的平均持续时间为64天(范围28至183天)。所有患者至少有1个可识别的医疗或手术风险因素,包括口服避孕药使用(2例)、吸烟(2例)、肥胖(2例)、关节镜辅助开放性手术(4例)或止血带使用时间>60分钟(3例)。

结论

青少年膝关节镜检查术后的VTE尚未得到充分描述。发生率约为0.25%。所有受影响人群中均存在先前确定的VTE风险因素。低分子量肝素成功治疗了这一并发症。

证据水平

IV级。

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