Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Thromb Res. 2019 Mar;175:90-94. doi: 10.1016/j.thromres.2019.01.011. Epub 2019 Jan 17.
Mean platelet volume (MPV) is a measure of platelet size and activity. We conducted a population study with National Health and Nutrition Examination Survey (NHANES) data to understand the relationship of MPV with health and diseases.
The NHANES is a cross-sectional survey of non-institutionalized adult population, administered every 2 years by the Centers for Disease Control and Prevention. Participants answer a questionnaire, receive a physical examination, and undergo laboratory tests. Values of MPV were collected over 6 years (2011-2016). Logistic regression was used to predict likelihood of being in categories with MPV < 10th percentile or >90th percentile. Statistical analysis was performed using Stata/SE 15.1.
In our study with 17,969 individuals, the mean MPV was 8.40 [SD = 0.92] femtoliter. Individuals with male sex, age 45-64 years, and recent hospital-stay were more likely to have MPV < 10th percentile. Obese, Blacks and Mexican Americans had higher odds of having MPV > 90th percentile. Individuals with emphysema had significantly higher adjusted Odds [OR 1.92, 95% CI: 1.11-3.31, p = 0.021] of MPV < 10th percentile. Individuals with cancer were less likely to have MPV > 90th percentile [OR 0.74, 95% CI: 0.55-0.99, p = 0.042]. A diagnosis of coronary artery disease, asthma, and chronic obstructive pulmonary disease did not have significant associations with MPV.
Obese individuals are more likely to have higher MPV. Individuals with emphysema had higher odds of having MPV < 10th percentile and those with cancer were less likely to have MPV > 90th percentile.
平均血小板体积（MPV）是血小板大小和活性的衡量标准。我们利用国家健康和营养检查调查（NHANES）的数据进行了一项人群研究，以了解 MPV 与健康和疾病的关系。
NHANES 是一项对非机构化成年人群进行的横断面调查，由疾病控制与预防中心每两年进行一次。参与者回答一份问卷，接受身体检查，并进行实验室测试。MPV 值在 6 年内收集（2011-2016 年）。使用逻辑回归预测 MPV<第 10 百分位数或>第 90 百分位数的可能性。使用 Stata/SE 15.1 进行统计分析。
在我们的研究中，有 17969 人，平均 MPV 为 8.40 [SD=0.92]飞升。男性、45-64 岁和最近住院的个体更有可能出现 MPV<第 10 百分位数。肥胖、黑人和墨西哥裔美国人出现 MPV>第 90 百分位数的几率更高。肺气肿患者的调整后优势比[OR 1.92，95%置信区间：1.11-3.31，p=0.021]显著更高，MPV<第 10 百分位数。癌症患者出现 MPV>第 90 百分位数的几率较低[OR 0.74，95%置信区间：0.55-0.99，p=0.042]。冠心病、哮喘和慢性阻塞性肺疾病的诊断与 MPV 无显著相关性。
肥胖个体更有可能出现更高的 MPV。肺气肿患者出现 MPV<第 10 百分位数的几率更高，而癌症患者出现 MPV>第 90 百分位数的几率较低。
