Erlangen Centre for Astroparticle Physics, Friedrich-Alexander-University Erlangen-Nuremberg, 91058 Erlangen, Germany.
Phys Med Biol. 2019 Mar 14;64(6):065013. doi: 10.1088/1361-6560/ab051c.
X-ray dark-field imaging is a promising technique for lung diagnosis. Due to the alveolar structure of lung tissue, a higher contrast is obtained by the dark-field image compared to the attenuation image. Animal studies indicate an enhancement regarding the detection of lung diseases in early stages. In this publication, we focus on the influence of different Talbot-Lau interferometer specifications while maintaining the x-ray source, sample magnification and detector system. By imaging the same porcine lung with three different grating sets, we analyze the contrast-to-noise ratio of the obtained dark-field images with respect to visibility and correlation length. We demonstrate that relatively large grating periods of the phase and of the analyzer grating are sufficient for high quality lung imaging at reasonable dose levels.
X 射线暗场成像是一种有前途的肺部诊断技术。由于肺组织的肺泡结构，与衰减图像相比，暗场图像获得了更高的对比度。动物研究表明，在早期检测肺部疾病方面有了增强。在本出版物中，我们专注于在保持 X 射线源、样品放大率和探测器系统不变的情况下，不同泰伯-劳（Talbot-Lau）干涉仪规格的影响。通过用三组不同的光栅对同一猪肺进行成像，我们分析了所获得的暗场图像的对比噪声比与可视性和相关长度的关系。我们证明，对于合理剂量水平的高质量肺部成像，相位和分析器光栅的相对较大的光栅周期是足够的。
