Magnussen I, Dupont E, Engbaek F, de Fine Olivarius B
Acta Neurol Scand. 1978 Apr;57(4):289-94. doi: 10.1111/j.1600-0404.1978.tb04502.x.
Post-hypoxic intention myoclonus successfully treated by long-term administration of the combination of 5-hydroxytryptophan and carbidopa is described. Persistent euphoria and diarrhoea were essential side effects. Methysergide (12 mg/day) blocked the therapeutic effect, indicating a specific serotoninergic function of precursor loading with 5-hydroxytryptophan. Tryptophan (8 g/day) had no effect on the myoclonus suggesting a reduced tryptophan hydroxylase activity. Plasma concentrations of 5-hydroxytryptophan in the range of 10--30 micromoles per liter were obtained during maintenance therapy with 900 mg 5-hydroxytryptophan per day in combination with 150 mg carbidopa per day.
描述了通过长期联合使用5-羟色氨酸和卡比多巴成功治疗缺氧后意向性肌阵挛的情况。持续性欣快感和腹泻是主要的副作用。麦角新碱（12毫克/天）可阻断治疗效果，表明5-羟色氨酸前体负荷具有特定的血清素能功能。色氨酸（8克/天）对肌阵挛没有影响，提示色氨酸羟化酶活性降低。在维持治疗期间，每天服用900毫克5-羟色氨酸并联合150毫克卡比多巴，可使血浆5-羟色氨酸浓度达到10 - 30微摩尔/升。
