• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

TWIST1 regulation of circRNA: a novel mechanism to promote epithelial-mesenchymal transition in hepatocellular carcinoma.

作者信息

Yochum Zachary A, Burns Timothy F

机构信息

Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.

Department of Medicine, Division of Hematology-Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.

出版信息

Noncoding RNA Investig. 2018 Dec;2. doi: 10.21037/ncri.2018.12.01. Epub 2018 Dec 19.

DOI:10.21037/ncri.2018.12.01
PMID:30734026
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6363344/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cca/6363344/5960ec8c8931/nihms-1003948-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cca/6363344/5960ec8c8931/nihms-1003948-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cca/6363344/5960ec8c8931/nihms-1003948-f0001.jpg

相似文献

1
TWIST1 regulation of circRNA: a novel mechanism to promote epithelial-mesenchymal transition in hepatocellular carcinoma.TWIST1对环状RNA的调控：一种促进肝细胞癌上皮-间质转化的新机制。
Noncoding RNA Investig. 2018 Dec;2. doi: 10.21037/ncri.2018.12.01. Epub 2018 Dec 19.
2
CASC15 promotes epithelial to mesenchymal transition and facilitates malignancy of hepatocellular carcinoma cells by increasing TWIST1 gene expression via miR-33a-5p sponging.CASC15 通过海绵吸附 miR-33a-5p 增加 TWIST1 基因表达促进上皮间质转化并促进肝癌细胞的恶性转化。
Eur J Pharmacol. 2019 Oct 5;860:172589. doi: 10.1016/j.ejphar.2019.172589. Epub 2019 Aug 8.
3
Promotion of hepatocellular carcinoma metastasis through matrix metalloproteinase activation by epithelial-mesenchymal transition regulator Twist1.上皮-间质转化调控因子 Twist1 通过基质金属蛋白酶的激活促进肝癌转移。
J Cell Mol Med. 2011 Mar;15(3):691-700. doi: 10.1111/j.1582-4934.2010.01052.x.
4
The role of Twist1 in hepatocellular carcinoma angiogenesis: a clinical study.Twist1 在肝细胞癌血管生成中的作用：一项临床研究。
Hum Pathol. 2011 Jun;42(6):840-7. doi: 10.1016/j.humpath.2010.03.010. Epub 2011 Jan 3.
5
Hypoxia induced epithelial-mesenchymal transition and vasculogenic mimicry formation by promoting Bcl-2/Twist1 cooperation.缺氧通过促进Bcl-2/Twist1协同作用诱导上皮-间质转化和血管生成拟态形成。
Exp Mol Pathol. 2015 Oct;99(2):383-91. doi: 10.1016/j.yexmp.2015.08.009. Epub 2015 Aug 28.
6
Protease-activated receptor-1 (PAR1) promotes epithelial-endothelial transition through Twist1 in hepatocellular carcinoma.蛋白酶激活受体-1（PAR1）通过 Twist1 促进肝癌中的上皮-内皮转化。
J Exp Clin Cancer Res. 2018 Aug 6;37(1):185. doi: 10.1186/s13046-018-0858-4.
7
Lipocalin-2 negatively modulates the epithelial-to-mesenchymal transition in hepatocellular carcinoma through the epidermal growth factor (TGF-beta1)/Lcn2/Twist1 pathway.载脂蛋白 L2 通过表皮生长因子（TGF-β1）/Lcn2/Twist1 通路负向调控肝癌细胞上皮间质转化。
Hepatology. 2013 Oct;58(4):1349-61. doi: 10.1002/hep.26467. Epub 2013 Aug 7.
8
Hypoxia promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells via inducing Twist1 expression.缺氧通过诱导 Twist1 表达促进肝癌细胞上皮-间充质转化。
Eur Rev Med Pharmacol Sci. 2017 Jul;21(13):3061-3068.
9
Sox12, a direct target of FoxQ1, promotes hepatocellular carcinoma metastasis through up-regulating Twist1 and FGFBP1.Sox12，FoxQ1 的一个直接靶标，通过上调 Twist1 和 FGFBP1 促进肝癌转移。
Hepatology. 2015 Jun;61(6):1920-33. doi: 10.1002/hep.27756. Epub 2015 Apr 8.
10
Metformin reverses bFGF-induced epithelial-mesenchymal transition in HCC cells.二甲双胍可逆转碱性成纤维细胞生长因子诱导的肝癌细胞上皮-间质转化。
Oncotarget. 2017 Oct 31;8(61):104247-104257. doi: 10.18632/oncotarget.22200. eCollection 2017 Nov 28.

引用本文的文献

1
Circular RNAs: Emblematic Players of Neurogenesis and Neurodegeneration.环状 RNA：神经发生和神经退行性变的标志性参与者。
Int J Mol Sci. 2022 Apr 8;23(8):4134. doi: 10.3390/ijms23084134.
2
Role of the epithelial-mesenchymal transition-related circular RNA, circ-10720, in non-small-cell lung cancer.上皮-间质转化相关环状RNA circ-10720在非小细胞肺癌中的作用
Transl Lung Cancer Res. 2021 Apr;10(4):1804-1818. doi: 10.21037/tlcr-20-920.

本文引用的文献

1
New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer.上皮-间质转化的机制新见解及其对癌症的影响。
Nat Rev Mol Cell Biol. 2019 Feb;20(2):69-84. doi: 10.1038/s41580-018-0080-4.
2
Circular RNAs as Therapeutic Agents and Targets.环状RNA作为治疗剂和靶点
Front Physiol. 2018 Oct 9;9:1262. doi: 10.3389/fphys.2018.01262. eCollection 2018.
3
Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small-cell lung cancer.靶向 EMT 转录因子 TWIST1 克服 EGFR 突变型非小细胞肺癌对 EGFR 抑制剂的耐药性。
Oncogene. 2019 Jan;38(5):656-670. doi: 10.1038/s41388-018-0482-y. Epub 2018 Aug 31.
4
Emerging function and potential diagnostic value of circular RNAs in cancer.环状 RNA 在癌症中的新兴功能和潜在诊断价值。
Mol Cancer. 2018 Aug 15;17(1):123. doi: 10.1186/s12943-018-0877-y.
5
Upregulation of circular RNA hsa_circ_0007534 predicts unfavorable prognosis for NSCLC and exerts oncogenic properties in vitro and in vivo.环状 RNA hsa_circ_0007534 的上调预示着 NSCLC 的预后不良，并在体外和体内发挥致癌作用。
Gene. 2018 Nov 15;676:79-85. doi: 10.1016/j.gene.2018.07.028. Epub 2018 Jul 11.
6
Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma.Twist1 通过 Cul2 环状 RNA 调节波形蛋白以促进肝癌中的 EMT。
Cancer Res. 2018 Aug 1;78(15):4150-4162. doi: 10.1158/0008-5472.CAN-17-3009. Epub 2018 May 29.
7
Increased circular RNA hsa_circ_0012673 acts as a sponge of miR-22 to promote lung adenocarcinoma proliferation.环状RNA hsa_circ_0012673表达增加通过充当miR-22的海绵促进肺腺癌增殖。
Biochem Biophys Res Commun. 2018 Feb 19;496(4):1069-1075. doi: 10.1016/j.bbrc.2018.01.126. Epub 2018 Jan 31.
8
Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM.上皮-间充质转化通过抑制 BIM 拮抗肺癌对靶向治疗的反应。
Clin Cancer Res. 2018 Jan 1;24(1):197-208. doi: 10.1158/1078-0432.CCR-17-1577. Epub 2017 Oct 19.
9
A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer.一类首创的 TWIST1 抑制剂，对驱动肺癌的致癌基因有活性。
Mol Cancer Res. 2017 Dec;15(12):1764-1776. doi: 10.1158/1541-7786.MCR-17-0298. Epub 2017 Aug 29.
10
Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway.环状RNA MYLK作为一种竞争性内源性RNA，通过调节VEGFA/VEGFR2信号通路促进膀胱癌进展。
Cancer Lett. 2017 Sep 10;403:305-317. doi: 10.1016/j.canlet.2017.06.027. Epub 2017 Jul 4.