Royal Randwick Medical Centre, 70/73-115 Belmore Road, Randwick NSW 203, Australia.
Acta Derm Venereol. 2019 May 1;99(6):551-556. doi: 10.2340/00015555-3144.
Concerns about topical steroid withdrawal are causing some patients to cease long-term topical corticosteroid therapy, however, little is known about the ensuing clinical outcomes. This qualitative case series studied 10 children whose parents stopped their chronic topical corticosteroid use and subsequently developed features typically reported in adults experiencing topical steroid withdrawal. Patients were seen in an Australian general practice between April 2014 and October 2018, with follow-up periods ranging from 18 months to 4 years. Symptoms were difficult initially for the children and their families, however, all ultimately improved. At the final review, 4 of the children had clear skin and another 4 had symptoms consistent with their original, pre-treatment atopic dermatitis. More research is required into long-term topical corticosteroid use and its discontinuation, including topical steroid withdrawal, particularly in the pediatric population.
人们对于局部皮质类固醇戒断的担忧导致一些患者停止长期局部皮质类固醇治疗，但对于随之而来的临床结果却知之甚少。本案例系列研究了 10 名儿童，其父母停止了他们的慢性局部皮质类固醇的使用，随后出现了成人中常报道的局部皮质类固醇戒断的特征。2014 年 4 月至 2018 年 10 月期间，这些患者在澳大利亚的一家普通诊所接受了治疗，随访期从 18 个月到 4 年不等。起初，这些孩子及其家人的症状都很难缓解，但最终都有所改善。在最后一次复查时，4 名儿童的皮肤状况明显改善，另外 4 名儿童的症状与他们之前的特应性皮炎一致。需要对长期局部皮质类固醇的使用及其停用，包括局部皮质类固醇戒断，特别是在儿科人群中进行更多的研究。
