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4例鱼鳞病样皮肤疾病合并瘢痕性脱发患者的头皮苔藓样毛囊炎。

Lichenoid folliculitis of the scalp in four patients with ichthyosiform skin disorders and cicatricial alopecia.

作者信息

Gavazzoni Dias Maria F R, Dutra Hudson, Trüeb Ralph, Vilar Enoí, Rochael Mayra, Quattrino Ada, Cury Amanda

机构信息

Department of Dermatology, Federal Fluminense University, Antonio Pedro University Hospital, Niterói, Brazil.

Department of Dermatology, Center for Dermatology and Hair Diseases Professor Trüeb, Wallisellen, Switzerland.

出版信息

J Cutan Pathol. 2019 Jun;46(6):431-435. doi: 10.1111/cup.13439. Epub 2019 Apr 3.

Abstract

Ichthyosis is a heterogeneous group of inherited skin disorders characterized by a defect of keratinization. Patients diagnosed with lamellar ichthyosis (LI) and some ichthyosiform syndromes, such as the Conradi-Hünermann-Happle syndrome (CHHS), usually present with hair loss. Even though only few dermatologic complaints carry as many emotional overtones as hair loss, there are very few data available in the literature regarding scalp histopathological features in ichthyosis. A better understanding of scalp changes in such context may result in new therapeutic strategies that in turn would enhance patients' self-esteem and quality of life. The aim of this paper is to describe the scalp histopathological findings of four young patients with cicatricial alopecia: three diagnosed as having LI and the fourth with CHHS.

摘要

鱼鳞病是一组遗传性皮肤疾病的统称,其特征为角质化缺陷。被诊断为板层状鱼鳞病(LI)和一些鱼鳞病样综合征,如康拉迪 - 于讷曼 - 哈普尔综合征(CHHS)的患者通常会出现脱发症状。尽管在皮肤科疾病中,很少有像脱发这样带有强烈情感色彩的症状,但关于鱼鳞病患者头皮组织病理学特征的文献资料却非常少。在这种情况下,更好地了解头皮变化可能会带来新的治疗策略,进而提高患者的自尊和生活质量。本文旨在描述4例瘢痕性脱发年轻患者的头皮组织病理学发现:其中3例被诊断为LI,第4例为CHHS。

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