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Using an old test for new tricks: Measuring direct oral anti-Xa drug levels by conventional heparin-calibrated anti-Xa assay.旧瓶装新酒：采用传统肝素校准的抗Xa测定法测量直接口服抗Xa药物水平
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An in vitro study to investigate the interference of enoxaparin on plasma levels of direct oral factor Xa inhibitors measured by chromogenic assays.一项体外研究，旨在调查依诺肝素对发色法检测的直接口服 Xa 因子抑制剂的血浆水平的干扰。
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Evaluation of a Heparin-Calibrated Antifactor Xa Assay for Measuring the Anticoagulant Effect of Oral Direct Xa Inhibitors.用于测量口服直接Xa因子抑制剂抗凝效果的肝素校准抗Xa因子检测法的评估
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Performance Assessment of a Multifaceted Unfractionated Heparin Dosing Protocol in Adult Patients on Extracorporeal Membrane Oxygenator.在体外膜肺氧合患者中使用多方面未分级肝素给药方案的性能评估。
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Can an anti-Xa assay for low-molecular-weight heparin be used to assess the presence of rivaroxaban?用于低分子量肝素的抗Xa测定能否用于评估利伐沙班的存在情况？
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Managing transitions from oral factor Xa inhibitors to unfractionated heparin infusions.处理从口服Xa因子抑制剂转换为普通肝素输注的过渡问题。
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Use of specific anti-Xa levels in acute kidney injury to transition patients from oral factor Xa inhibitors to i.v. heparin infusion.在急性肾损伤中使用特定的抗 Xa 水平，将接受口服因子 Xa 抑制剂治疗的患者转换为静脉注射肝素输注。
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Direct Oral Anticoagulants (DOACs) in the Laboratory: 2015 Review.直接口服抗凝剂（DOACs）在实验室中的应用：2015 年回顾。
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Heparin Anti-Xa Activity, a Readily Available Unique Test to Quantify Apixaban, Rivaroxaban, Fondaparinux, and Danaparoid Levels.肝素抗 Xa 活性：一种可用于定量检测阿哌沙班、利伐沙班、磺达肝癸钠和达那肝素水平的独特检测方法。
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Srp Arh Celok Lek. 2016 Nov-Dec;144(11-12):654-6.

引用本文的文献

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Challenges to Laboratory Monitoring of Direct Oral Anticoagulants.直接口服抗凝剂的实验室监测挑战。
Clin Appl Thromb Hemost. 2024 Jan-Dec;30:10760296241241524. doi: 10.1177/10760296241241524.
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Usefullness of Heparin Calibrated Anti-Xa Activity to Assess Anticoagulant Activity of Apixaban and Rivaroxaban in Emergency Patients Scheduled for Acute Interventions.肝素校准抗Xa活性用于评估计划进行急性干预的急诊患者中阿哌沙班和利伐沙班抗凝活性的效用。
J Clin Med. 2023 Oct 26;12(21):6785. doi: 10.3390/jcm12216785.
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Practical Nomogram Predicting Apixaban or Rivaroxaban Concentrations from Low-Molecular-Weight Heparin Anti-Xa Values: Special Interest in Acute Ischemic Stroke Patients.根据低分子量肝素抗Xa值预测阿哌沙班或利伐沙班浓度的实用列线图：对急性缺血性中风患者的特别关注
J Stroke. 2023 Jan;25(1):126-131. doi: 10.5853/jos.2022.03034. Epub 2023 Jan 3.
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Accuracy of a Single, Heparin-Calibrated Anti-Xa Assay for the Measurement of Rivaroxaban, Apixaban, and Edoxaban Drug Concentrations: A Prospective Cross-Sectional Study.用于测量利伐沙班、阿哌沙班和依度沙班药物浓度的单一肝素校准抗Xa测定法的准确性：一项前瞻性横断面研究。
Front Cardiovasc Med. 2022 Mar 17;9:817826. doi: 10.3389/fcvm.2022.817826. eCollection 2022.
5
Author Reply to "Intravenous thrombolysis in patients taking direct oral anticoagulants (European stroke organisation intravenous thrombolysis guidelines comment).作者对《正在服用直接口服抗凝剂的患者的静脉溶栓治疗（欧洲卒中组织静脉溶栓指南评论）》的回复
Eur Stroke J. 2021 Dec;6(4):447-449. doi: 10.1177/23969873211058566. Epub 2021 Nov 15.
6
Anticoagulation Monitoring for Perioperative Physicians.围手术期医师的抗凝监测。
Anesthesiology. 2021 Oct 1;135(4):738-748. doi: 10.1097/ALN.0000000000003903.

本文引用的文献

1
Testing and monitoring direct oral anticoagulants.检测和监测直接口服抗凝剂。
Blood. 2018 Nov 8;132(19):2009-2015. doi: 10.1182/blood-2018-04-791541. Epub 2018 Sep 10.
2
Heparin-calibrated chromogenic anti-Xa assays are not suitable to assess the presence of significant direct factor Xa inhibitors levels.
Thromb Res. 2017 Aug;156:36-38. doi: 10.1016/j.thromres.2017.05.024. Epub 2017 May 25.
3
Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors.安达西尼α用于治疗与Xa因子抑制剂相关的急性大出血。
N Engl J Med. 2016 Sep 22;375(12):1131-41. doi: 10.1056/NEJMoa1607887. Epub 2016 Aug 30.
4
When and how to use antidotes for the reversal of direct oral anticoagulants: guidance from the SSC of the ISTH.何时以及如何使用解毒剂逆转直接口服抗凝剂：来自国际血栓与止血学会（ISTH）科学与标准化委员会（SSC）的指南
J Thromb Haemost. 2016 Mar;14(3):623-7. doi: 10.1111/jth.13227. Epub 2016 Feb 17.
5
Evaluation of a Heparin-Calibrated Antifactor Xa Assay for Measuring the Anticoagulant Effect of Oral Direct Xa Inhibitors.用于测量口服直接Xa因子抑制剂抗凝效果的肝素校准抗Xa因子检测法的评估
Clin Appl Thromb Hemost. 2016 Jul;22(5):423-8. doi: 10.1177/1076029616629759. Epub 2016 Feb 2.
6
Heparin-Calibrated Chromogenic Anti-Xa Activity Measurements in Patients Receiving Rivaroxaban: Can This Test Be Used to Quantify Drug Level?接受利伐沙班治疗的患者中肝素校准的发色底物法抗Xa活性测定：该检测能否用于定量药物水平？
Ann Pharmacother. 2015 Jul;49(7):777-83. doi: 10.1177/1060028015578451. Epub 2015 Apr 8.

Using an old test for new tricks: Measuring direct oral anti-Xa drug levels by conventional heparin-calibrated anti-Xa assay.

作者信息

Maier Cheryl L, Asbury William H, Duncan Alexander, Robbins Adele, Ingle Ann, Webb Adam, Stowell Sean R, Roback John D

机构信息

Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.

Department of Pharmacy, Emory University Hospital, Atlanta, Georgia.

出版信息

Am J Hematol. 2019 May;94(5):E132-E134. doi: 10.1002/ajh.25434. Epub 2019 Feb 21.

DOI:10.1002/ajh.25434
PMID:30734369
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8668051/
Abstract
摘要