Haave Hilde, Gulati Sahil, Brekke Jorunn, Lybak Stein, Vintermyr Olav K, Aarstad Hans Jørgen
a Department of ENT/Head and Neck Surgery , Haukeland University Hospital , Bergen , Norway.
b Department of ENT/Head and Neck surgery , Haukeland Universitetssjukehus , Bergen , Norway.
Acta Otolaryngol. 2018 Nov;138(11):1035-1042. doi: 10.1080/00016489.2018.1497809. Epub 2019 Feb 8.
Oropharyngeal squamous cell carcinoma (OPSCC) positive for human papillomavirus (HPV) increases wolrd wide.
AIMS/OBJECTIVES: The objective for this study has been to evaluate tumor phenotypes and tumor host responses with respect to five-year disease-specific survival (DSS) in HPV(+) and HPV(-) patients.
Two hundred patients with OPSCC have been treated between 1992 and 2010. Histopathology slides from these patients have been morphologically evaluated in formalin-fixed, paraffin-embedded (FFPE) stained with hematoxylin-eosin (HE). From HE-stained sections tumor phenotype (keratinization, fraction of mature cancer cells and pattern of invasion) and tumor host responses (inflammation and stromal desmoplasia) were evaluated with respect to five years DSS.
High tumor inflammatory response and low stromal desmoplasia had an independent effect predicting better five-year DSS among all patients and when analyzed separately in the HPV(-) and HPV(+) cohort of patients using a Cox regression survival analysis that also included standard clinical prognostic variables among OPSCC patients.
Tumor host responses, inflammation and stromal desmoplasia may become part of routine work-up in OPSCC patients due to prognostic value.
We present a method, accessible in most clinical locations and would give important additional information about prognosis in OPSCC patients.
人乳头瘤病毒（HPV）阳性的口咽鳞状细胞癌（OPSCC）在全球范围内呈上升趋势。
本研究的目的是评估HPV阳性和HPV阴性患者的肿瘤表型及肿瘤宿主反应与五年疾病特异性生存率（DSS）的关系。
1992年至2010年间对200例OPSCC患者进行了治疗。对这些患者的组织病理学切片在福尔马林固定、石蜡包埋（FFPE）、苏木精-伊红（HE）染色后进行形态学评估。从HE染色切片中评估肿瘤表型（角化、成熟癌细胞比例和浸润模式）及肿瘤宿主反应（炎症和间质纤维组织增生）与五年DSS的关系。
在所有患者中，以及在HPV阴性和HPV阳性患者队列中分别使用Cox回归生存分析（该分析还纳入了OPSCC患者的标准临床预后变量）进行分析时，高肿瘤炎症反应和低间质纤维组织增生对预测更好的五年DSS具有独立作用。
由于具有预后价值，肿瘤宿主反应、炎症和间质纤维组织增生可能成为OPSCC患者常规检查的一部分。
我们提出了一种在大多数临床场所都可采用的方法，该方法能为OPSCC患者的预后提供重要的额外信息。
