Cecenarro Rodolfo Raúl, Bonci Laura, Kasparian Andrés, Gramática H Luis
Servicio de Cirugía General N°I - Hospital Nacional de Clínicas - FCM - UNC.
Rev Fac Cien Med Univ Nac Cordoba. 2018 Nov 13;75(4):240-247. doi: 10.31053/1853.0605.v75.n3.18420.
Acute pancreatitis (AP) is an inflammatory disease of the pancreas that spans a wide range ranging from mild to critical forms. Contrary to the progress in the management of severe AP, the MAP has not presented significant changes in recent years. There are also no studies that establish a clear relationship between EEN in MAP and levels of albuminemia and CRP.
A randomized, longitudinal and prospective clinical study was conducted. Patients were divided into 2 groups. The experimental group (G1) was indicated from the entrance a diet hyperproteic low in colecistokinetics diet, and to the control group (G2) nothing by mouth.
19 patients were randomly distributed in 57.89% in the G2 and 42.11% in the G1. The G1 presented a higher average hospital stay in relation to the G2, such differences were not significant (p> 0.05). The G1 presented higher values of CRP in relation to the G2 significantly (p ?0.05). There was a decrease in albumin levels in both groups (p ?0.05). It was observed in both groups that, as CRP levels increased, albumin levels decreased significantly (p <0.01).
Albuminemia levels decreased significantly in both groups, and this decrease was more marked in the EEN group. The decrease in albuminemia had a direct correlation with CRP levels, which were higher in the G1.
急性胰腺炎（AP）是一种胰腺炎症性疾病，其严重程度范围从轻度到重症。与重症急性胰腺炎治疗方面的进展相反，近年来轻症急性胰腺炎（MAP）并无显著变化。也没有研究明确MAP中早期肠内营养（EEN）与白蛋白血症水平和C反应蛋白（CRP）之间的关系。
开展了一项随机、纵向和前瞻性临床研究。患者被分为两组。实验组（G1）从入院起即给予高蛋白、低胆囊收缩素饮食，对照组（G2）则禁食。
19例患者被随机分配，57.89%在G2组，42.11%在G1组。G1组的平均住院时间相对于G2组更长，但这种差异不显著（p>0.05）。G1组的CRP值相对于G2组显著更高（p≤0.05）。两组的白蛋白水平均有所下降（p≤0.05）。两组均观察到，随着CRP水平升高，白蛋白水平显著下降（p<0.01）。
两组的白蛋白血症水平均显著下降，且在EEN组中这种下降更为明显。白蛋白血症的下降与G1组中更高的CRP水平直接相关。
