Volkova A R, Dygun O D, Katysheva N S, Bondarenko V L, Maltseva M N, Belyakova L A, Emanuel V L
FSBEI HE «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of Russian Federation, 197022, Saint Petersburg, Russia.
Klin Lab Diagn. 2018;63(9):538-542. doi: 10.18821/0869-2084-2018-63-9-538-542.
The prevalence of subclinical hypothyroidism (SH) is large and according to various studies is from 3 to 21%. In the Russian Federation to date, there are no major epidemiological studies assessing the functional state of the thyroid gland. It seems relevant to study the TSH level in patients who turned to the clinical units of a large hospital in the North-West region to determine the prevalence of thyroid dysfunction in patients of different sex and age. 5,303 patients were examined, who applied to the I.P. Pavlov SPbSMU clinics for 2017. In all patients the level of TSH and free T4 was determined. SH was considered to increase the level of TSH more than 4.0 mIU/l at a normal level of free T4. Patients were divided into groups by age and TSH level in accordance with existing recommendations. Among the examined patients were 29.26% of men and 70.73% of women. The mean age was 55.08 ± 17.07 years. The TSH level had an abnormal distribution and averaged 2.77 mIU/l (TSH median 1.73 mIU/l). In women the level of TSH was significantly higher in all studied groups of patients (p = 0.0001). Among women, significant differences in the level of TSH between the elderly and young patients (p = 0.015) were found. The incidence of SH in the total group of patients was 10.1%. In the men surveyed, the incidence of SH was 7.3%, and in the female group - 11.3%. In the elderly patients, the incidence of subclinical hypothyroidism in women was 2 times higher than that of men. In most cases (77.4%) in patients with SH, the TSH level was in the range of 4.0-6.9 mIU / L. The clinical significance of minimal thyroid insufficiency requires further study.
亚临床甲状腺功能减退（SH）的患病率很高，根据各项研究，其患病率在3%至21%之间。在俄罗斯联邦，迄今为止尚无评估甲状腺功能状态的大型流行病学研究。研究西北地区一家大型医院临床科室患者的促甲状腺激素（TSH）水平，以确定不同性别和年龄患者甲状腺功能障碍的患病率似乎很有必要。对2017年到圣彼得堡巴甫洛夫第一医科大学诊所就诊的5303例患者进行了检查。测定了所有患者的TSH水平和游离甲状腺素（T4）水平。当游离T4水平正常时，TSH水平超过4.0 mIU/L被认为是SH。根据现有建议，患者按年龄和TSH水平分组。在接受检查的患者中，男性占29.26%，女性占70.73%。平均年龄为55.08±17.07岁。TSH水平呈异常分布，平均为2.77 mIU/L（TSH中位数为1.73 mIU/L）。在所有研究的患者组中，女性的TSH水平显著更高（p = 0.0001）。在女性中，老年患者和年轻患者的TSH水平存在显著差异（p = 0.015）。患者总数中SH的发病率为10.1%。在接受调查的男性中，SH的发病率为7.3%，在女性组中为11.3%。在老年患者中，女性亚临床甲状腺功能减退的发病率是男性的2倍。在大多数情况下（77.4%），SH患者的TSH水平在4.0 - 6.9 mIU/L范围内。轻微甲状腺功能不全的临床意义需要进一步研究。
