Department of Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
PLoS One. 2019 Feb 8;14(2):e0210945. doi: 10.1371/journal.pone.0210945. eCollection 2019.
The aim of this study was to assess the association between CHA2DS2-VASc score and carotid plaques in patients with non-valvular atrial fibrillation (NVAF).
We conducted a retrospective study including 3,435 NVAF patients who underwent carotid ultrasound examinations from January 2015 to December 2017.We collected the clinical data on the medical records system. Chi-square trend test was used to analyze trends between the prevalence of carotid plaques with an increasing CHA2DS2-VASc score. Univariate and multivariate logistic regression was also used to assess the association between carotid plaques and CHA2DS2-VASc scores. The area under the receiver operating characteristic (ROC) curve (AUC) was used to determine the optimal cutoff points of different CHA2DS2-VASc scores in NVAF patients.
NVAF patients with carotid plaques had higher CHA2DS2-VASc scores compared with patients who did not have carotid plaques (3.01±1.36 vs. 2.55±1.28, P < 0.05). In all participants, male participants and female participants, the prevalence of carotid plaques increased significantly as the CHA2DS2-VASc score increased (P for trend < 0.001). Multivariate logistic regression analysis demonstrated that for each 1-point increase in the CHA2DS2-VASc score, there was an associated 37% increase in the prevalence of carotid plaques. ROC curve analysis revealed that a CHA2DS2-VASc score ≥ 2 in male patients (sensitivity, 44.67%; specificity, 75.64%; AUC, 0.639) or ≥ 3 in female patients (sensitivity, 47.24%; specificity, 72.40%; AUC, 0.634) were associated with carotid plaques.
The prevalence of carotid plaques in patients with NVAF was associated with the CHA2DS2-VASc score.
本研究旨在评估 CHA2DS2-VASc 评分与非瓣膜性心房颤动（NVAF）患者颈动脉斑块之间的关系。
我们进行了一项回顾性研究，纳入了 2015 年 1 月至 2017 年 12 月期间接受颈动脉超声检查的 3435 例 NVAF 患者。我们从病历系统中收集了临床数据。卡方趋势检验用于分析随着 CHA2DS2-VASc 评分的增加，颈动脉斑块的患病率趋势。单因素和多因素逻辑回归也用于评估颈动脉斑块与 CHA2DS2-VASc 评分之间的关系。接收者操作特征（ROC）曲线下面积（AUC）用于确定不同 CHA2DS2-VASc 评分在 NVAF 患者中的最佳截断点。
与无颈动脉斑块的患者相比，有颈动脉斑块的 NVAF 患者的 CHA2DS2-VASc 评分更高（3.01±1.36 与 2.55±1.28，P<0.05）。在所有参与者中，男性参与者和女性参与者中，随着 CHA2DS2-VASc 评分的增加，颈动脉斑块的患病率显著增加（趋势 P<0.001）。多因素逻辑回归分析表明，CHA2DS2-VASc 评分每增加 1 分，颈动脉斑块的患病率增加 37%。ROC 曲线分析显示，男性患者 CHA2DS2-VASc 评分≥2（敏感性，44.67%；特异性，75.64%；AUC，0.639）或女性患者 CHA2DS2-VASc 评分≥3（敏感性，47.24%；特异性，72.40%；AUC，0.634）与颈动脉斑块相关。
NVAF 患者颈动脉斑块的患病率与 CHA2DS2-VASc 评分相关。
