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孕期晚期失眠与围产期焦虑有关:一项纵向队列研究。

Insomnia late in pregnancy is associated with perinatal anxiety: A longitudinal cohort study.

机构信息

Department of Psychiatry, Ålesund Hospital, Møre & Romsdal Health Trust, Ålesund, Norway; Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Department of Psychiatry, Ålesund Hospital, Møre & Romsdal Health Trust, Ålesund, Norway; Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway; Centre for Research and Education in Forensic Psychiatry, Oslo University Hospital, Oslo, Norway.

出版信息

J Affect Disord. 2019 Apr 1;248:155-165. doi: 10.1016/j.jad.2019.01.027. Epub 2019 Jan 28.

Abstract

BACKGROUND

Postpartum anxiety (PPA) affects a substantial number of women. Despite increasing recognition of PPA, few studies have focused on perinatal anxiety and potential PPA triggers. Here we aimed to estimate the prevalence of perinatal anxiety disorders, and to explore the association between insomnia during late pregnancy and anxiety before and after childbirth.

METHODS

This study was part of the large population-based Akershus Birth Cohort. We analyzed data from the hospital's birth records and questionnaire responses from pregnancy weeks 17 and 32 and postpartum week 8 (n = 1563). Perinatal anxiety symptoms were measured using the Hopkins Symptom Check List. Anxiety disorder measurements were based on questions from the Mini-International Neuropsychiatric Interview. Insomnia was measured using the Bergen Insomnia Scale.

RESULTS

Among perinatal women, 10% reported symptoms of at least one anxiety disorder. The observed prevalence of obsessive-compulsive disorder was higher after delivery (4.2%) than during pregnancy (2.5%). Multiple regression analysis, with adjustment for several psychosocial and reproductive variables, indicated that insomnia during pregnancy was significantly associated with postpartum anxiety symptoms. However, this association was markedly weakened when depression variables were included in the analysis, indicating that gestational insomnia may also be a marker for a mood disorder.

LIMITATIONS

Immigrant and single women were underrepresented in our sample.

CONCLUSIONS

Our results suggest that anxiety disorders are prevalent during the perinatal period. Moreover, insomnia during pregnancy is associated with perinatal anxiety. Health professionals should be aware that women with gestational insomnia may have an increased risk of mood and anxiety disorders.

摘要

背景

产后焦虑症(PPA)影响了大量女性。尽管人们对 PPA 的认识不断提高,但很少有研究关注围产期焦虑症和潜在的 PPA 触发因素。在这里,我们旨在估计围产期焦虑症的患病率,并探讨妊娠晚期失眠与分娩前后焦虑之间的关系。

方法

本研究是阿克什胡斯出生队列的大型人群研究的一部分。我们分析了医院出生记录和妊娠第 17 周和第 32 周以及产后第 8 周的问卷调查答复数据(n=1563)。围产期焦虑症状使用霍普金斯症状检查清单进行测量。焦虑症的测量基于迷你国际神经精神访谈中的问题。失眠使用卑尔根失眠量表进行测量。

结果

在围产期女性中,有 10%报告至少有一种焦虑症症状。观察到的强迫症患病率在分娩后(4.2%)高于妊娠期间(2.5%)。多项回归分析,调整了几个心理社会和生殖变量,表明妊娠期间失眠与产后焦虑症状显著相关。然而,当分析中包括抑郁变量时,这种关联明显减弱,这表明妊娠期失眠也可能是情绪障碍的一个标志。

局限性

我们的样本中代表性不足的移民和单身女性。

结论

我们的结果表明,焦虑症在围产期很常见。此外,妊娠期间失眠与围产期焦虑症相关。卫生专业人员应该意识到,有妊娠失眠的女性可能有更高的情绪和焦虑障碍风险。

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