Centre for Environment and Population Health, Griffith School of Environment and Science, Griffith University, 170 Kessel Road, Nathan, QLD 4111, Australia.
Centre for Environment and Population Health, Griffith School of Environment and Science, Griffith University, 170 Kessel Road, Nathan, QLD 4111, Australia.
Ecotoxicol Environ Saf. 2019 May 15;172:439-443. doi: 10.1016/j.ecoenv.2019.01.077. Epub 2019 Feb 6.
Chlorpyrifos is one of the most widely used organophosphate pesticides and has a record of adverse effects on applicators. Assessment of exposure to chlorpyrifos based on its urinary metabolite, 3,5,6-trichloro-2-pyridinol (TCP), is considered as the most accurate. However, urine sampling can be difficult, and the laboratory analytical procedures involved are complex and expensive. A simpler approach for assessing pesticide exposure among applicators is the whole-body dermal dosimetry method, but this needs validation. The objective of this study was to compare chlorpyrifos exposure estimates obtained separately with the urinary TCP and the whole-body dermal dosimetry methods from applicators. Exposure estimates from the whole-body dermal dosimetry method (5-29 μg/kg/day) showed less variation than those from the urinary TCP method (1-71 μg/kg/day), but both were in close agreement at the mean level (16 μg/kg/day and 15 μg/kg/day, respectively). The whole-body dermal dosimetry method is therefore valid for providing estimates of the typical levels of pesticide exposure among applicators in situations where the urinary TCP method cannot be applied.
毒死蜱是最广泛使用的有机磷农药之一，有记录显示其对施药者有不良影响。基于其尿代谢物 3,5,6-三氯-2-吡啶醇（TCP）来评估接触情况被认为是最准确的。然而，尿样采集可能很困难，而且涉及的实验室分析程序复杂且昂贵。一种更简单的方法是对施药者进行全身皮肤剂量测定，但需要验证。本研究的目的是比较单独使用尿 TCP 和全身皮肤剂量测定方法从施药者获得的毒死蜱接触估计值。全身皮肤剂量测定法（5-29μg/kg/天）得到的接触估计值变化小于尿 TCP 法（1-71μg/kg/天），但平均值上两者非常接近（分别为 16μg/kg/天和 15μg/kg/天）。因此，在无法应用尿 TCP 法的情况下，全身皮肤剂量测定法可用于为施药者提供典型的农药接触水平的估计值。
