The Impulse Response of Negatively Focused Spherical Ultrasound Detectors and Its Effect on Tomographic Optoacoustic Reconstruction.

In optoacoustic tomography, negatively focused detectors have been shown to improve the tangential image resolution without sacrificing sensitivity. Since no exact inversion formulas exist for optoacoustic image reconstruction with negatively focused detectors, image reconstruction in such cases is based on using the virtual-detector approximation, in which it is assumed that the response of the negatively focused detector is identical, up to a constant time delay, to that of a point-like detector positioned in the detector's center of curvature. In this paper, we analyze the response of negatively focused spherical ultrasound detectors in three dimensions and demonstrate how their properties affect the optoacoustic reconstruction. Our analysis sheds new light on commonly reported experimental reconstruction artifacts in optoacoustic systems that employ negatively focused detectors. Based on our analysis, we introduce a simple correction to the virtual-detector approximation that significantly enhances image contrast and reduces artifacts.