Institute for Biological and Medical Imaging (IBMI), Technical University of Munich and Helmholtz Center Munich, Ingoldstädter Landstrasse 1, Neuherberg 85764, Germany.
Opt Lett. 2012 Oct 1;37(19):4080-2. doi: 10.1364/OL.37.004080.
Optoacoustic (photoacoustic) mesoscopic and microscopic imaging is often implemented by linearly scanning a spherically focused ultrasound transducer. In this case, the resolution and sensitivity along the scan direction are limited by diffraction and therefore degrade rapidly for imaging depths away from the focal point. Partial restoration of the lost resolution can be achieved by using data-processing techniques, such as the virtual detector delay-and-sum method. However, these techniques are based on an approximate description of the detector properties, which limits the improvement in image quality they achieve. Herein we propose a reconstruction method based on an exact model of the optoacoustic generation and propagation that incorporates the spatial response of the sensor. The proposed method shows superior imaging performance over previously considered techniques.
光声（超声）介观和微观成像是通过线性扫描球形聚焦超声换能器来实现的。在这种情况下，扫描方向上的分辨率和灵敏度受到衍射的限制，因此对于远离焦点的成像深度，分辨率会迅速下降。通过使用数据处理技术，如虚拟探测器延迟求和法，可以部分恢复丢失的分辨率。然而，这些技术是基于对探测器特性的近似描述，这限制了它们所能实现的图像质量的提高。本文提出了一种基于光声产生和传播的精确模型的重建方法，该方法将传感器的空间响应纳入其中。与以前考虑的技术相比，所提出的方法显示出优越的成像性能。
