Abbott David H
a Department of Obstetrics and Gynecology and Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA.
Expert Rev Endocrinol Metab. 2012 Jan;7(1):31-34. doi: 10.1586/eem.11.90.
Evaluation of: Hatzirodos N, Bayne RA, Irving-Rodgers HF et al. Linkage of regulators of TGF-β activity in the fetal ovary to polycystic ovary syndrome. FASEB J. 25(7), 2256-2265 (2011). Polycystic ovary syndrome (PCOS), a prevalent hyperandrogenic and anovulatory infertility and metabolic syndrome in reproductive-aged women, is heritable but its etiology is unknown. An allele within an intron of fibrillin-3, a TGF-β pathway regulator, is reliably associated with PCOS, and the epigenome of an early gestation monkey model for PCOS implicates altered TGF-β signaling. In the recent article by Hatzirodos et al., and in contrast to prior findings in mature human ovaries, prominent and transient fibrillin-3 expression is found in human and bovine fetal ovarian stroma during early gestation. Such developmentally constrained ovarian expression of a gene associated with PCOS phenotype has considerable implications for fetal origins of PCOS in women. Further study is needed, however, to determine whether differential expression of fetal ovarian fibrillin-3 results in polycystic ovary morphology, and whether differential fetal expression of fibrillin-3 in non-ovarian tissues enables PCOS-like dysfunction.
哈齐罗多斯N、贝恩RA、欧文 - 罗杰斯HF等人。胎儿卵巢中转化生长因子 - β（TGF - β）活性调节因子与多囊卵巢综合征的关联。《美国实验生物学联合会会刊》。第25卷第7期，2256 - 2265页（2011年）。多囊卵巢综合征（PCOS）是育龄女性中一种常见的高雄激素血症、无排卵性不孕和代谢综合征，具有遗传性，但其病因尚不清楚。作为TGF - β通路调节因子的原纤蛋白 - 3内含子中的一个等位基因与PCOS可靠相关，并且PCOS早期妊娠猴模型的表观基因组表明TGF - β信号发生了改变。在哈齐罗多斯等人最近的文章中，与之前在成熟人类卵巢中的发现相反，在妊娠早期的人类和牛胎儿卵巢基质中发现了显著且短暂的原纤蛋白 - 3表达。这种与PCOS表型相关基因在卵巢发育过程中的受限表达对女性PCOS的胎儿起源具有重要意义。然而，还需要进一步研究来确定胎儿卵巢原纤蛋白 - 3的差异表达是否会导致多囊卵巢形态，以及非卵巢组织中原纤蛋白 - 3的胎儿差异表达是否会导致类似PCOS的功能障碍。
