QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD 4006, Australia.
QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD 4006, Australia.
Trends Pharmacol Sci. 2019 Mar;40(3):198-211. doi: 10.1016/j.tips.2019.01.005. Epub 2019 Feb 6.
Breast cancer is one of the most common cancers affecting women. Despite significant improvements in overall survival, it remains a significant cause of death worldwide. Genomic instability (GI) is a hallmark of cancer and plays a pivotal role in breast cancer development and progression. In the past decade, high-throughput technologies have provided a wealth of information that has facilitated the identification of a diverse repertoire of mutated genes and mutational processes operative across cancers. Here, we review recent findings on genomic alterations and mutational processes in breast cancer pathogenesis. Most importantly, we summarize the clinical challenges and opportunities to utilize omics-based signatures for better management of breast cancer patients and treatment decision-making.
乳腺癌是影响女性的最常见癌症之一。尽管整体生存率有了显著提高，但它仍然是全球范围内导致死亡的一个重要原因。基因组不稳定性（GI）是癌症的一个标志，在乳腺癌的发生和发展中起着关键作用。在过去的十年中，高通量技术提供了大量的信息，有助于识别跨癌症存在的多样化的突变基因和突变过程。在这里，我们回顾了乳腺癌发病机制中基因组改变和突变过程的最新发现。最重要的是，我们总结了利用基于组学的特征来更好地管理乳腺癌患者和治疗决策的临床挑战和机遇。
