《鼻炎和哮喘患者视角问卷》（RAPP）葡萄牙语版的验证和评估。
The Portuguese version of Rhinitis and Asthma Patient's Perspective (RAPP): Validation and assessment.
机构信息
Faculty of Medicina, University of Coimbra and Immunoallergology Department, Coimbra University Hospital, Portugal.
Department of Internal Medicine, Respiratory Diseases and Allergy Clinic, University of Genova - Azienda Policlinico IRCCs San Martino, Genova, Italy.
出版信息
Pulmonology. 2020 Mar-Apr;26(2):73-77. doi: 10.1016/j.pulmoe.2018.10.009. Epub 2019 Feb 5.
BACKGROUND
Allergic rhinitis (AR) and asthma are two common chronic diseases that often coexist. There is a need for a validated tool to evaluate HRQoL of Portuguese speakers with asthma and/or rhinitis patients in clinical practice.
OBJECTIVES
To adapt and validate RhinAsthma Patient Perspective (RAPP) in Portuguese.
METHODS
The RAPP questionnaire was translated into Portuguese. Asthmatics with comorbidities and rhinitis attending the allergy department of Coimbra University Hospital were asked to complete the Portuguese translation of RAPP, in addition to the SF-12, ACT, and a Symptomatologic VAS twice, with a 4-week interval between visits. During Visit 2, a Global Rating Scale (GRS) was completed to assess any change in health status. Scale dimensions, internal consistency and convergent validity, reliability, discriminant ability and responsiveness to change, as well as Minimal Clinical Difference were assessed.
RESULTS
Factor and confirmatory analysis confirm the unidimensional structure of the questionnaire. Internal consistency has been shown to be satisfactory (0.82 visit 1 and 0.86 at visit 2). The tool is able to discriminate between patients on the basis of asthma severity, asthma control level, and rhinitis severity; convergent validity showed a significant correlation with SF-2 Physical component (r=-0.46 and 0.42, p at Visits 1 and 2). An ICC of 0.97 and a CCC=0.94 indicate that the tool is highly reliable. Responsiveness was shown in detecting a significant association with GRS changes (r=0.41, p<0.01) and ACT (r=-0.47, p<0.01) but not with VAS. (r=.14, n.s.). MID value was 2 points.
CONCLUSIONS
The Portuguese version of RAPP has been demonstrated to have good measurement properties and sensitivity to health changes, which will provide a valid, reliable and standardized HRQoL measurement in patients with asthma and comorbid allergic rhinitis in clinical practice.
背景
过敏性鼻炎（AR）和哮喘是两种常见的慢性疾病，常并存。需要有一种经过验证的工具来评估临床实践中患有哮喘和/或鼻炎的葡萄牙语患者的健康相关生活质量（HRQoL）。
目的
将 RhinAsthma Patient Perspective（RAPP）适应并验证为葡萄牙语。
方法
RAPP 问卷被翻译为葡萄牙语。患有合并症的哮喘患者和在科英布拉大学医院过敏科就诊的鼻炎患者被要求完成 RAPP 葡萄牙语翻译，此外还完成了 SF-12、ACT 和症状 VAS 两次，两次就诊之间间隔 4 周。在就诊 2 时，完成总体评分量表（GRS）以评估健康状况的任何变化。评估了量表维度、内部一致性和收敛有效性、可靠性、判别能力和对变化的反应能力以及最小临床差异。
结果
因子和验证性分析证实了问卷的单维结构。内部一致性被证明是令人满意的（就诊 1 时为 0.82，就诊 2 时为 0.86）。该工具能够根据哮喘严重程度、哮喘控制水平和鼻炎严重程度来区分患者；收敛有效性显示与 SF-2 生理成分（r=-0.46 和 0.42，就诊 1 和 2 时 p 值均<0.01）显著相关。0.97 的 ICC 和 0.94 的 CCC 表明该工具具有高度可靠性。响应性表明，与 GRS 变化（r=0.41，p<0.01）和 ACT（r=-0.47，p<0.01）显著相关，但与 VAS 无关（r=.14，n.s.）。MID 值为 2 分。
结论
证明了 RAPP 的葡萄牙语版本具有良好的测量特性和对健康变化的敏感性，这将为临床实践中患有哮喘和合并过敏性鼻炎的患者提供有效的、可靠的和标准化的 HRQoL 测量。
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