Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, M. Asias 75, GR-11527, Athens, Greece.
Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.
Cell Stress Chaperones. 2019 Mar;24(2):469-473. doi: 10.1007/s12192-019-00978-0. Epub 2019 Feb 8.
The cellular stress response (CSR) is a universal inducible reaction modulated, among others, by heat, drugs, and hormones. We aimed to investigate the role of L-thyroxine (T4) on the heat shock (HS) response in Saccharomyces cerevisiae. The CSR was evaluated by determining growth and viability of post-logarithmic phase grown yeast cultures after HS at 53 °C for 30 min. We found that long-term T4 exposure can induce a dose-dependent and Hsp90 and H trafficking-related thermotolerance in yeast.
细胞应激反应 (CSR) 是一种普遍的诱导反应,可被热、药物和激素等因素调节。我们旨在研究 L-甲状腺素 (T4) 在酿酒酵母的热休克 (HS) 反应中的作用。通过测定对数期后生长的酵母培养物在 53°C 下 30 分钟 HS 后的生长和活力来评估 CSR。我们发现,长期 T4 暴露可以诱导酵母产生剂量依赖性和 Hsp90 和 H 转运相关的耐热性。