Teesalu R, Kòrgevee A
Tartu State University, Estonian SSR, USSR.
Biomed Biochim Acta. 1988;47(10-11):S56-9.
Continuous intravenous infusion of prostacyclin (PGI2) was carried out for 30 to 120 min at the rates 25, 50, 75, 100 ng/kg/min in 149 experiments in 30 anesthetized dogs. PGI2 caused significant dose-dependent rise in heart rate, cardiac output, stroke volume and mean coronary artery blood flow. At the same time arterial blood pressures, total peripheral resistance and coronary vascular resistance decreased significantly while pulmonary artery pressures, central venous pressure, mean femoral artery blood flow and pressure rise velocity in left ventricle remained practically unaltered. Stady state of hemodynamic parameters was reached in 10 to 12 min. after the beginning of infusion. After discontinuation of infusion of PGI2 the values of recorded hemodynamic parameters returned to pre-infusion level in 10 to 15 min. Hemodynamic changes were well reproducible during repetitive infusions of PGI2 The purpose of this study was to determine the effects of PGI2 on various hemodynamic parameters.
在30只麻醉犬身上进行了149次实验，以25、50、75、100 ng/kg/分钟的速率持续静脉输注前列环素（PGI2）30至120分钟。PGI2导致心率、心输出量、每搏量和平均冠状动脉血流量显著的剂量依赖性升高。同时，动脉血压、总外周阻力和冠状动脉血管阻力显著降低，而肺动脉压、中心静脉压、平均股动脉血流量和左心室压力上升速度基本保持不变。输注开始后10至12分钟达到血流动力学参数的稳定状态。停止输注PGI2后，记录的血流动力学参数值在10至15分钟内恢复到输注前水平。在重复输注PGI2期间，血流动力学变化具有良好的可重复性。本研究的目的是确定PGI2对各种血流动力学参数的影响。
