Ershov Dmitry, Minc Nicolas
Institut Jacques Monod, CNRS UMR7592, Paris, France.
Université Paris Diderot, Paris, France.
Methods Mol Biol. 2019;1920:393-406. doi: 10.1007/978-1-4939-9009-2_24.
The division patterns of early invertebrate and vertebrate embryos are key to the specification of cell fates and embryo body axes. We here describe a generic computational modeling method to quantitatively test mechanisms which specify successive division position and orientation of eggs and early blastomeres in 3D. This approach should serve to motivate and guide future experimental work on the mechanisms controlling early embryo morphogenesis.
早期无脊椎动物和脊椎动物胚胎的分裂模式是细胞命运和胚胎体轴特化的关键。我们在此描述一种通用的计算建模方法，用于定量测试在三维空间中确定卵子和早期卵裂球连续分裂位置和方向的机制。这种方法应有助于推动和指导未来关于控制早期胚胎形态发生机制的实验工作。
