Celik Mustafa, Koyuncu İsmail
Department of Otorhinolaryngology, Harran University School of Medicine, Osmanbey Campus, Haliliye, Sanliurfa, 63300, Turkey.
Department of Biochemistry, Harran University School of Medicine, Osmanbey Campus, Haliliye, Sanliurfa, 63300, Turkey.
Int J Pediatr Otorhinolaryngol. 2019 Apr;119:177-182. doi: 10.1016/j.ijporl.2019.01.039. Epub 2019 Jan 31.
The aim of this study is to investigate oxidative stress conditions in patients with prelingual profound sensorineural hearing loss (SNHL) and the effects of cochlear implant application on oxidative stress. In addition, we also aimed to evaluate the correlation between pre- and post-surgery oxidative stress markers and Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS), Meaningful Use of Speech Scale (MUSS) and Free-Field Audiometry (FFA).
This is a prospective controlled study of the Ear-Nose-Throat Department of the Harran University Faculty of Medicine between April 2017 and January 2018. The study included 25 patients with prelingual profound SNHL diagnosis and cochlear implant surgery and 25 healthy control groups. Total thiol, native thiol, disulphide levels and LOOH levels were studied in serum samples taken from the patient group 2 weeks before and 6 months after the cochlear implant surgery and the healthy control group. In addition, IT-MAIS, MUSS and FFA tests, which were used to evaluate the personal development of patients with cochlear implants, were performed at preoperative and postoperative 6th month.
In our study, we found that the levels of native thiol (p < 0.01) and total thiol (p < 0.01) were significantly lower and LOOH (p < 0.04) values were significantly higher in preoperative SNHL patients than control group. We found that native thiol, total thiol values increased and LOOH values decreased in the postoperative with respect to preoperative values. However, the difference between preoperative and post operative values was not statistically significant. The correlation between pre- and post-surgery biochemical data and IT-MAIS, MUSS and FFA tests were found not to be significant.
Our study suggests that patients with prelingual profound SNHL are under oxidative stress and post-CI surgery data show that there is no significant relief in patients. This study can shed light on the biologic mechanisms between prelingual profound SNHL and oxidative stress.
本研究旨在调查语前极重度感音神经性听力损失（SNHL）患者的氧化应激状况以及人工耳蜗植入对氧化应激的影响。此外，我们还旨在评估手术前后氧化应激标志物与婴幼儿有意义听觉整合量表（IT - MAIS）、言语有意义使用量表（MUSS）和自由声场听力测定（FFA）之间的相关性。
这是一项于2017年4月至2018年1月在哈兰大学医学院耳鼻喉科进行的前瞻性对照研究。该研究纳入了25例经诊断为语前极重度SNHL并接受人工耳蜗植入手术的患者以及25个健康对照组。在人工耳蜗植入手术前2周和术后6个月从患者组以及健康对照组采集的血清样本中研究总硫醇、天然硫醇、二硫键水平和LOOH水平。此外，在术前和术后第6个月进行IT - MAIS、MUSS和FFA测试，以评估人工耳蜗植入患者的个人发育情况。
在我们的研究中，我们发现术前SNHL患者的天然硫醇水平（p < 0.01）和总硫醇水平（p < 0.01）显著低于对照组，而LOOH（p < 0.04）值显著高于对照组。我们发现术后天然硫醇、总硫醇值相对于术前值有所增加，而LOOH值有所下降。然而，术前和术后值之间的差异无统计学意义。发现手术前后生化数据与IT - MAIS、MUSS和FFA测试之间的相关性不显著。
我们的研究表明，语前极重度SNHL患者处于氧化应激状态，人工耳蜗植入术后的数据显示患者并无明显缓解。本研究可为语前极重度SNHL与氧化应激之间的生物学机制提供线索。
