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本文引用的文献

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Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group.双相障碍的皮质异常：来自 ENIGMA 双相障碍工作组的 6503 个人的 MRI 分析。
Mol Psychiatry. 2018 Apr;23(4):932-942. doi: 10.1038/mp.2017.73. Epub 2017 May 2.
2
Cortical Morphology Characteristics of Young Offspring of Patients With Schizophrenia or Bipolar Disorder.精神分裂症或双相障碍患者子代的皮质形态学特征。
J Am Acad Child Adolesc Psychiatry. 2017 Jan;56(1):79-88. doi: 10.1016/j.jaac.2016.09.516. Epub 2016 Oct 25.
3
Inter-Method Discrepancies in Brain Volume Estimation May Drive Inconsistent Findings in Autism.脑容量估计中的方法间差异可能导致自闭症研究结果不一致。
Front Neurosci. 2016 Sep 30;10:439. doi: 10.3389/fnins.2016.00439. eCollection 2016.
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Cortical thickness in symptomatic and asymptomatic bipolar offspring.症状性和无症状性双相后代的皮质厚度。
Psychiatry Res Neuroimaging. 2016 May 30;251:26-33. doi: 10.1016/j.pscychresns.2016.04.007. Epub 2016 Apr 13.
5
Abnormalities in left inferior frontal gyral thickness and parahippocampal gyral volume in young people at high genetic risk for bipolar disorder.双相情感障碍高遗传风险的年轻人左下额回厚度和海马旁回体积异常。
Psychol Med. 2016 Jul;46(10):2083-96. doi: 10.1017/S0033291716000507. Epub 2016 Apr 12.
6
Abnormal white matter integrity as a structural endophenotype for bipolar disorder.异常的白质完整性作为双相情感障碍的一种结构内表型。
Psychol Med. 2016 May;46(7):1547-58. doi: 10.1017/S0033291716000180. Epub 2016 Mar 7.
7
Cortical thickness in bipolar disorder: a systematic review.双相情感障碍中的皮质厚度：一项系统综述。
Bipolar Disord. 2016 Feb;18(1):4-18. doi: 10.1111/bdi.12362. Epub 2016 Feb 6.
8
Cortical thickness, volume and surface area in patients with bipolar disorder types I and II.I型和II型双相情感障碍患者的皮质厚度、体积和表面积。
J Psychiatry Neurosci. 2016 Jun;41(4):240-50. doi: 10.1503/jpn.150093.
9
Distinguishing bipolar and major depressive disorders by brain structural morphometry: a pilot study.通过脑结构形态测量区分双相情感障碍和重度抑郁症：一项初步研究。
BMC Psychiatry. 2015 Nov 21;15:298. doi: 10.1186/s12888-015-0685-5.
10
Manic episodes are related to changes in frontal cortex: a longitudinal neuroimaging study of bipolar disorder 1.躁狂发作与额皮质变化有关：双相障碍 1 项纵向神经影像学研究。
Brain. 2015 Nov;138(Pt 11):3440-8. doi: 10.1093/brain/awv266. Epub 2015 Sep 15.

双相障碍 I 型患者及其一级亲属的皮质厚度和表面积作为内表型。

Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives.

机构信息

Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Department of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey.

Department of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey; Department of Psychiatry, Faculty of Medicine, Katip Celebi University, Izmir, Turkey.

出版信息

Neuroimage Clin. 2019;22:101695. doi: 10.1016/j.nicl.2019.101695. Epub 2019 Jan 29.

DOI:10.1016/j.nicl.2019.101695
PMID:30738374
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6370861/
Abstract

OBJECTIVES

So far, few studies have investigated cortical thickness (CT) and surface area (SA) measures in bipolar disorder type I (BDI) in comparison to a high genetic risk group such as first-degree relatives (FR). This study aimed to examine CT and SA differences between BDI, FR and healthy controls (HC).

METHODS

3D T1 magnetic resonance images were acquired from 27 euthymic BDI patients, 24 unaffected FR and 29 HC. CT and SA measures were obtained with FreeSurfer version 5.3.0. Generalized estimating equations were used to compare CT and SA between groups. Group comparisons were repeated with restricting the FR group to 17 siblings (FR-SB) only.

RESULTS

\Mean age in years was 36.3 ± 9.5 for BDI, 32.1 ± 10.9 for FR, 34.7 ± 9.8 for FR-SB and 33.1 ± 9.0 for HC group respectively. BDI patients revealed larger SA of left pars triangularis (LPT) compared to HC (p = .001). In addition, increased SA in superior temporal cortex (STC) in FR-SB group compared to HC was identified (p = .0001).

CONCLUSIONS

Our result of increased SA in LPT of BDI could be a disease marker and increased SA in STC of FR-SB could be a marker related with resilience to illness.

摘要

目的

迄今为止，鲜有研究将脑皮质厚度（CT）和脑表面积（SA）测量值与双相情感障碍 I 型（BDI）与一级亲属（FR）等高遗传风险组进行比较。本研究旨在比较 BDI、FR 和健康对照组（HC）之间的 CT 和 SA 差异。

方法

从 27 名病情稳定的 BDI 患者、24 名未受影响的 FR 和 29 名 HC 中获取 3D T1 磁共振图像。使用 FreeSurfer 版本 5.3.0 获得 CT 和 SA 测量值。使用广义估计方程比较组间 CT 和 SA。仅将 FR 组限制为 17 名兄弟姐妹（FR-SB），重复组间比较。

结果

BDI 组的平均年龄为 36.3±9.5 岁，FR 组为 32.1±10.9 岁，FR-SB 组为 34.7±9.8 岁，HC 组为 33.1±9.0 岁。BDI 患者左三角部（LPT）的 SA 大于 HC（p=0.001）。此外，还发现 FR-SB 组的上颞叶皮质（STC）SA 增加（p=0.0001）。

结论

我们发现 BDI 的 LPT 中 SA 增加可能是疾病标志物，而 FR-SB 的 STC 中 SA 增加可能是与疾病易感性相关的标志物。