双相障碍 I 型患者及其一级亲属的皮质厚度和表面积作为内表型。
Cortical thickness and surface area as an endophenotype in bipolar disorder type I patients and their first-degree relatives.
机构信息
Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Department of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey.
Department of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey; Department of Psychiatry, Faculty of Medicine, Katip Celebi University, Izmir, Turkey.
出版信息
Neuroimage Clin. 2019;22:101695. doi: 10.1016/j.nicl.2019.101695. Epub 2019 Jan 29.
OBJECTIVES
So far, few studies have investigated cortical thickness (CT) and surface area (SA) measures in bipolar disorder type I (BDI) in comparison to a high genetic risk group such as first-degree relatives (FR). This study aimed to examine CT and SA differences between BDI, FR and healthy controls (HC).
METHODS
3D T1 magnetic resonance images were acquired from 27 euthymic BDI patients, 24 unaffected FR and 29 HC. CT and SA measures were obtained with FreeSurfer version 5.3.0. Generalized estimating equations were used to compare CT and SA between groups. Group comparisons were repeated with restricting the FR group to 17 siblings (FR-SB) only.
RESULTS
\Mean age in years was 36.3 ± 9.5 for BDI, 32.1 ± 10.9 for FR, 34.7 ± 9.8 for FR-SB and 33.1 ± 9.0 for HC group respectively. BDI patients revealed larger SA of left pars triangularis (LPT) compared to HC (p = .001). In addition, increased SA in superior temporal cortex (STC) in FR-SB group compared to HC was identified (p = .0001).
CONCLUSIONS
Our result of increased SA in LPT of BDI could be a disease marker and increased SA in STC of FR-SB could be a marker related with resilience to illness.
目的
迄今为止，鲜有研究将脑皮质厚度（CT）和脑表面积（SA）测量值与双相情感障碍 I 型（BDI）与一级亲属（FR）等高遗传风险组进行比较。本研究旨在比较 BDI、FR 和健康对照组（HC）之间的 CT 和 SA 差异。
方法
从 27 名病情稳定的 BDI 患者、24 名未受影响的 FR 和 29 名 HC 中获取 3D T1 磁共振图像。使用 FreeSurfer 版本 5.3.0 获得 CT 和 SA 测量值。使用广义估计方程比较组间 CT 和 SA。仅将 FR 组限制为 17 名兄弟姐妹（FR-SB），重复组间比较。
结果
BDI 组的平均年龄为 36.3±9.5 岁，FR 组为 32.1±10.9 岁，FR-SB 组为 34.7±9.8 岁，HC 组为 33.1±9.0 岁。BDI 患者左三角部（LPT）的 SA 大于 HC（p=0.001）。此外，还发现 FR-SB 组的上颞叶皮质（STC）SA 增加（p=0.0001）。
结论
我们发现 BDI 的 LPT 中 SA 增加可能是疾病标志物，而 FR-SB 的 STC 中 SA 增加可能是与疾病易感性相关的标志物。
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