National Coordinating Centre for the Physics of Mammography, Royal Surrey County Hospital, Guildford, Surrey, UK; Medical School, University of Cyprus, Nicosia, Cyprus.
National Coordinating Centre for the Physics of Mammography, Royal Surrey County Hospital, Guildford, Surrey, UK.
Phys Med. 2019 Jan;57:25-32. doi: 10.1016/j.ejmp.2018.11.014. Epub 2018 Dec 18.
Digital breast tomosynthesis (DBT) is currently under consideration for replacement of, or combined use with 2D-mammography in national breast screening programmes. To investigate the potential benefits that DBT can bring to screening, the threshold detectable lesion diameters were measured for different forms of DBT in comparison to 2D-mammography. The aim of this study was to compare the threshold detectable mass diameters obtained with narrow angle (15°/15 projections) and wide angle (50°/25 projections) DBT in comparison to 2D-mammography. Simulated images of 60 mm thick compressed breasts were produced with and without masses using a set of validated image modelling tools for 2D-mammography and DBT. Image processing and reconstruction were performed using commercial software. A series of 4-alternative forced choice (4AFC) experiments was conducted for signal detection with the masses as targets. The threshold detectable mass diameter was found for each imaging modality with a mean glandular dose of 2.5 mGy. The resulting values of the threshold diameter for 2D-mammography (10.2 ± 1.4 mm) were found to be larger (p < 0.001) than those for narrow angle DBT (6.0 ± 1.1 mm) and wide angle DBT (5.6 ± 1.2 mm). There was no significant difference between the threshold diameters for wide and narrow angle DBT. Implications for the introduction of DBT alone or in combination with 2D-mammography in breast cancer screening are discussed.
数字乳腺断层合成术（DBT）目前正被考虑用于替代或与二维乳腺摄影术联合用于国家乳腺筛查计划。为了研究 DBT 给筛查带来的潜在益处，测量了不同形式的 DBT 与二维乳腺摄影术相比，检测到病变的可检测阈值直径。本研究的目的是比较窄角（15°/15 个投影）和宽角（50°/25 个投影）DBT 与二维乳腺摄影术相比，检测到的可检测肿块直径。使用一组经过验证的二维乳腺摄影术和 DBT 的图像建模工具，模拟了有或没有肿块的 60mm 厚压缩乳房的图像。使用商业软件进行图像处理和重建。使用一系列 4 种备选强迫选择（4AFC）实验进行信号检测，将肿块作为目标。对于每种成像方式，在平均腺体剂量为 2.5mGy 时，都可以找到可检测肿块的阈值直径。二维乳腺摄影术（10.2±1.4mm）的阈值直径值（p<0.001）大于窄角 DBT（6.0±1.1mm）和宽角 DBT（5.6±1.2mm）的阈值直径值。宽角和窄角 DBT 的阈值直径之间没有显著差异。讨论了在乳腺癌筛查中单独引入 DBT 或与二维乳腺摄影术联合使用的影响。
