Christian C L
Arthritis Rheum. 1978 Jun;21(5 Suppl):S130-3.
There are clear indications that genetic variables influence the pathogenesis of SLE. The frequency of the disease in first-degree relatives of SLE subjects appears to be in the range of 1-2%, but this is in great excess relative to the frequency of SLE in the general population. The frequency of concordance of the disease in monozygotic twin pairs is in excess of 50%. The frequency of concordance of dizygotic twins may be no higher than that in other first-degree relatives. Data in twins support the conclusion that familial aggregation is due to genetic rather than to other familial factors. The high female-to-male ratio of patients with SLE may reflect sex hormonal influence on immunoreactivity rather than the genetic aspects of sex per se. The approximately threefold higher incidence of SLE in black subjects relative to white, in some studies, may reflect a heightened activity of the humoral immune system in blacks.
有明确迹象表明基因变量会影响系统性红斑狼疮（SLE）的发病机制。SLE患者一级亲属中该病的发病率似乎在1%至2%的范围内，但相对于一般人群中SLE的发病率而言，这一比例要高得多。同卵双胞胎中该病的一致率超过50%。异卵双胞胎的一致率可能并不高于其他一级亲属。双胞胎的数据支持这样的结论，即家族聚集是由基因而非其他家族因素导致的。SLE患者中女性与男性的比例较高，这可能反映了性激素对免疫反应性的影响，而非性别本身的基因方面。在一些研究中，黑人SLE的发病率比白人高约三倍，这可能反映了黑人体液免疫系统的活性增强。
