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表现为腭部溃疡的上颌窦结外弥漫性大B细胞淋巴瘤

Extranodal diffuse large B cell lymphoma of maxillary sinus presenting as a palatal ulcer.

作者信息

Janardhanan Mahija, Suresh Rakesh, Savithri Vindhya, Veeraraghavan Ravi

机构信息

Department of Oral Pathology and Microbiology, Amrita School of Dentistry,AIMS Campus,Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Department of Oral Surgery, Amrita School of Dentistry, AIMS Campus, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

出版信息

BMJ Case Rep. 2019 Feb 9;12(2):e228605. doi: 10.1136/bcr-2018-228605.

Abstract

A multitude of disease processes ranging from periodontitis to malignancies can lead to formation of solitary ulcer on the palate. Hence solitary ulcers of palate can often be a challenging one to diagnose. We report an interesting case of a diffuse large B cell lymphoma of the maxillary sinus which perforated the palatal bone and presented clinically as a palatal ulcer. Initially the lesion manifested as a small ill-defined swelling in the posterior palatal slope in relation to 24and25 which were mobile and hence was erroneously diagnosed as chronic periodontal abscess. This paper is intended to stress the relevance of including non-Hodgkin's lymphoma in the differential diagnosis of solitary palatal ulcers as it may be often misdiagnosed as more common reactive or inflammatory lesions.

摘要

从牙周炎到恶性肿瘤等多种疾病过程都可能导致腭部出现孤立性溃疡。因此,腭部孤立性溃疡的诊断往往具有挑战性。我们报告一例有趣的上颌窦弥漫性大B细胞淋巴瘤病例,该肿瘤穿透腭骨,临床上表现为腭部溃疡。最初,病变表现为腭后缘与24和25相关的边界不清的小肿块,牙齿松动,因此被误诊为慢性牙周脓肿。本文旨在强调在孤立性腭部溃疡的鉴别诊断中纳入非霍奇金淋巴瘤的相关性,因为它常常可能被误诊为更常见的反应性或炎性病变。

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本文引用的文献

1
Diagnosis and classification of lymphoma: Impact of technical advances.淋巴瘤的诊断和分类:技术进步的影响。
Semin Hematol. 2019 Jan;56(1):30-36. doi: 10.1053/j.seminhematol.2018.05.007. Epub 2018 May 29.
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B-cell receptor signaling in diffuse large B-cell lymphoma.弥漫性大B细胞淋巴瘤中的B细胞受体信号传导
Semin Hematol. 2015 Apr;52(2):77-85. doi: 10.1053/j.seminhematol.2015.01.008. Epub 2015 Jan 15.
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Nat Rev Clin Oncol. 2014 Jan;11(1):12-23. doi: 10.1038/nrclinonc.2013.197. Epub 2013 Nov 12.
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Diffuse large B-cell lymphoma.弥漫性大 B 细胞淋巴瘤。
Crit Rev Oncol Hematol. 2013 Aug;87(2):146-71. doi: 10.1016/j.critrevonc.2012.12.009. Epub 2013 Jan 30.

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