Uneyama Mizuho, Chambers James K, Miyama Kouki, Miwa Yasutsugu, Uchida Kazuyuki, Nakayama Hiroyuki
Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Miwa Exotic Animal Hospital, 1-25-5 Komagome, Toshima-ku, Tokyo 170-0003, Japan.
J Toxicol Pathol. 2019 Jan;32(1):49-55. doi: 10.1293/tox.2018-0030. Epub 2018 Oct 8.
Adrenal disorders are common in ferrets, but there are few studies on cystic lesions of the adrenal gland. The present study describes pathological and immunohistochemical features of adrenal cysts in eleven ferrets and discusses their histogenesis. In nine of eleven cases examined, which included seven, one, and one right, left, and bilateral cases, respectively, cysts were in the adrenal cortex and lined with epithelial cells. These epithelial cells contained an Alcian blue-negative/PAS-positive material and were positive for cytokeratin (CK) 7. The staining pattern was similar to that of biliary epithelial cells in the ferret. In five of the cases, there were small ducts adjacent to the cysts that were positive for CK7 and CK20 and negative for CK19. Based on the anatomical proximity between the right adrenal and liver, the immunohistochemical features of the small duct cells were comparable to those of hepatic oval cells. These results indicate the possibility that these adrenocortical cysts in the ferret originated from the biliary system. In the other two cases, the cysts lacked an epithelial cell lining, and there were dilated lymphoid vessels around the cysts. These cysts were assumed to have developed in the adrenal medulla, because the cyst wall was positive for glial fibrillary acidic protein and there were adrenal medullary cells positive for synaptophysin in the cyst wall. Therefore, the medullary cysts may have been associated with dilated vasculatures.
肾上腺疾病在雪貂中很常见，但关于肾上腺囊性病变的研究很少。本研究描述了11只雪貂肾上腺囊肿的病理和免疫组化特征，并讨论了它们的组织发生。在11例检查病例中的9例中，分别包括7例、1例和1例右侧、左侧和双侧病例，囊肿位于肾上腺皮质，内衬上皮细胞。这些上皮细胞含有阿尔辛蓝阴性/过碘酸希夫染色阳性物质，细胞角蛋白（CK）7呈阳性。染色模式与雪貂胆管上皮细胞相似。在5例病例中，囊肿附近有小导管，CK7和CK20呈阳性，CK19呈阴性。基于右肾上腺与肝脏的解剖学邻近性，小导管细胞的免疫组化特征与肝卵圆细胞相似。这些结果表明，雪貂的这些肾上腺皮质囊肿可能起源于胆道系统。在另外2例病例中，囊肿缺乏上皮细胞内衬，囊肿周围有扩张的淋巴管。这些囊肿被认为是在肾上腺髓质中形成的，因为囊肿壁胶质纤维酸性蛋白呈阳性，囊肿壁中有突触素呈阳性的肾上腺髓质细胞。因此，髓质囊肿可能与血管扩张有关。
