Abhyankar Vrushali P, Bates Amber M, Fischer Carol L, Johnson Georgia K, Guthmiller Janet M, Progulske-Fox Ann, Brogden Kim A
Department of Periodontology, University of Tennessee, College of Dentistry, TN 38163, USA.
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
Data Brief. 2018 Dec 31;22:964-970. doi: 10.1016/j.dib.2018.12.087. eCollection 2019 Feb.
Chemokines and cytokines produced in gingival tissues exposed to microorganisms and microbial products in dental plaque lead to local inflammation and tissue damage seen in periodontal disease. Bates et al. 2018 [1] reported that hemagglutinin B (HagB)-induced matrix metalloproteinase (MMP) responses of single cell cultures containing dendritic cells, gingival epithelial (GE) keratinocytes, or T cells were significantly different from the MMP responses of these same cells grown in multi-cell cultures. Here we report the concentrations (pg/ml) of HagB-induced IL1α, IL6, IL8, IL12(p40), GM-CSF, MIP1α, MIP1β, RANTES, TNFα, and VEGF produced by dendritic cells, GE keratinocytes, or T cells in single cell cultures, two-cell cultures, or three-cell cultures.
暴露于牙菌斑中的微生物和微生物产物时，牙龈组织中产生的趋化因子和细胞因子会导致牙周疾病中出现的局部炎症和组织损伤。贝茨等人在2018年报道，血凝素B（HagB）诱导的含有树突状细胞、牙龈上皮（GE）角质形成细胞或T细胞的单细胞培养物的基质金属蛋白酶（MMP）反应，与这些相同细胞在多细胞培养物中生长时的MMP反应显著不同。在此，我们报告了树突状细胞、GE角质形成细胞或T细胞在单细胞培养物、双细胞培养物或三细胞培养物中产生的HagB诱导的IL1α、IL6、IL8、IL12（p40）、GM-CSF、MIP1α、MIP1β、RANTES、TNFα和VEGF的浓度（pg/ml）。
