Rauchfuß Falk, Helble Julian, Bruns Johanna, Dirsch Olaf, Dahmen Uta, Ardelt Michael, Settmacher Utz, Scheuerlein Hubert
Department of General, Visceral and Vascular Surgery, Jena University Hospital, 07747 Jena, Germany.
Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, JenaUniversity Hospital, 07747 Jena, Germany.
Nanomaterials (Basel). 2019 Feb 10;9(2):236. doi: 10.3390/nano9020236.
Ventral or incisional hernia are a common disease pattern in general surgery. Mostcommonly, a mesh repair is used for reconstruction, whereby the mesh itself might causecomplications, like infections or adhesions. Biological materials, like biocellulose, might reducethese clinical problems substantially. In this prospective rodent study, a biocellulose mesh(produced by Gluconacetobacter xylinus) was implanted either by a sublay technique or assupplementation of the abdominal wall. After an observation period of 90 days, animals weresacrificed. The adhesions after the reconstruction of the abdominal wall were moderate. Thehistologic investigations revealed that the biocellulose itself was inert, with a minimal regenerativeresponse surrounding the mesh. The explanted mesh showed a minimal shrinkage (around 15%) aswell as a minimal loss of tear-out force, which might be without clinical relevance. This is the firstin vivo study describing biocellulose as a suitable mesh for the repair of ventral hernia in twodifferent hernia models. The material seems to be a promising option for solving actual problems inmodern hernia surgery.
腹疝或切口疝是普通外科的常见病症。最常用的方法是使用补片进行修复，但补片本身可能会引发感染或粘连等并发症。生物材料，如生物纤维素，可能会大幅减少这些临床问题。在这项前瞻性啮齿动物研究中，通过腹膜前植入技术或作为腹壁补片植入了一种生物纤维素补片（由木醋杆菌属生产）。经过90天的观察期后，处死动物。腹壁重建后的粘连程度为中度。组织学研究表明，生物纤维素本身是惰性的，补片周围的再生反应极小。取出的补片收缩极小（约15%），撕裂力损失也极小，这可能与临床无关。这是第一项在两种不同疝模型中描述生物纤维素作为修复腹疝合适补片的体内研究。这种材料似乎是解决现代疝手术实际问题的一个有前景的选择。
