P Pallavee, Samal Rupal, Ghose Seetesh
a Department of Obstetrics and Gynecology , Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed-to-be-University) , Puducherry , India.
J Obstet Gynaecol. 2019 May;39(4):582-583. doi: 10.1080/01443615.2018.1534815. Epub 2019 Feb 11.
Although the incidence of chronic myeloid leukaemia (CML) in pregnancy is low, it is progressively rising. The management strategies for CML patients during pregnancy include tyrosine kinase inhibitors, interferon alpha, leukapheresis and hydroxyurea, each of which has their own deleterious effects on the mother and foetus. There are virtually no accepted guidelines on the therapeutic options for these patients. We report two cases of CML which were reported to us during pregnancy, on imatinib, with different ultimate pregnancy outcomes. We do believe that it is high time professional bodies frame guidelines for the management of these patients.
尽管妊娠期间慢性髓性白血病（CML）的发病率较低，但呈逐渐上升趋势。CML患者妊娠期间的管理策略包括酪氨酸激酶抑制剂、α干扰素、白细胞单采术和羟基脲，每种策略对母亲和胎儿都有各自的有害影响。对于这些患者的治疗选择，实际上没有公认的指南。我们报告两例妊娠期间向我们报告的CML病例，均使用伊马替尼治疗，但最终妊娠结局不同。我们确实认为，专业机构制定这些患者管理指南的时候到了。
