Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, China.
BMC Public Health. 2019 Feb 11;19(1):172. doi: 10.1186/s12889-019-6485-y.
Maternal family history of diabetes was significantly and positively associated with birth weight in grandchildren, we aim to assess the effect of grandparental diabetes on the grandchild' body mass index (BMI) at infancy peak (IP) and obesity status at age 2.
In our study, family diabetes mellitus (DM) information from Ma'anshan Birth Cohort Study (MABC) were gathered. For children, height and weight were retrieved from medical records. BMI at 6 observations (0, 3, 6, 9, 12, 18 months) was plotted for every child. Onset of IP was determined by visual inspection. BMI at age 2 was categorized according to WHO Child Growth Standards as normal, overweight or obesity. The association between maternal grandfather' diabetes and the grandchild' BMI at IP and BMI at age 2 were tested using linear regression models and logistic regression models, respectively.
In our sample, about 6% of the maternal grandfather had DM, mean of infancy BMI peak was 18.37 kg/m, and 6.6% of the children were obesity at age 2. Maternal grandfather with DM could significantly increase the IP BMI values (β = 0.30, 95 CI = 0.020.57), and was associated with obesity status at age 2 (OR = 1.92, 95 CI = 1.083.39), but maternal grandmother and paternal grandparents were unrelated.
These results suggest that DM in maternal grandfather may be a risk factor for the grandchild high BMI at peak and obesity at age 2.
祖母或祖父有糖尿病家族史与孙辈的出生体重显著正相关，本研究旨在评估祖辈糖尿病对婴幼儿期体重峰值（infancy peak，IP）时的外孙/孙女体重指数（body mass index，BMI）和 2 岁时肥胖状态的影响。
本研究收集了来自马鞍山市出生队列研究（Ma'anshan Birth Cohort Study，MABC）的家族糖尿病史信息。对于儿童，身高和体重数据从病历中获取。为每个孩子绘制了 6 次（0、3、6、9、12、18 个月）的 BMI 变化图。通过肉眼观察确定 IP 的起始时间。根据世界卫生组织儿童生长标准，将 2 岁时的 BMI 分为正常、超重或肥胖。使用线性回归模型和逻辑回归模型分别检验了母系外祖父的糖尿病与外孙/孙女的 IP 时 BMI 和 2 岁时 BMI 的相关性。
在我们的样本中，约 6%的母系外祖父患有糖尿病，婴幼儿期 BMI 峰值的平均值为 18.37kg/m2，6.6%的儿童在 2 岁时肥胖。患有糖尿病的母系外祖父可显著增加 IP 时的 BMI 值（β=0.30，95%置信区间=0.020.57），并且与 2 岁时的肥胖状态相关（OR=1.92，95%置信区间=1.083.39），但母系外祖母和父系祖辈与外孙/孙女的 BMI 无相关性。
这些结果表明，母系外祖父的糖尿病可能是外孙/孙女在婴幼儿期体重峰值和 2 岁时肥胖的一个危险因素。
