School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
J Nanosci Nanotechnol. 2019 Jun 1;19(6):3616-3620. doi: 10.1166/jnn.2019.16124.
The nanoscale drug-loaded micelles can be prepared by the supercritical carbon dioxide evaporation method. Here, response surface methodology is used to optimize this process. The effects of pressure, ScCO₂ release rate and the volume ratio of water against ScCO₂ on the drug entrapment efficiency (EE) of the obtained micelles are discussed in detail. The obtained second-order polynomial equation can successfully predict the drug EE of the drug-loaded micelles. The maximum EE can reach 70.1% under optimal conditions in which the pressure is 12.27 MPa, the release rate is 10 L min and the volume ratio of water against ScCO₂ is 3.67:1. The prepared micelles exhibit a narrow size distribution and relatively regularly spherical shape. drug release study reveals that the release of paclitaxel from the micelles is slow and sustained.
载药纳米胶束可通过超临界二氧化碳蒸发法制备。本文采用响应面法对该工艺进行优化。详细讨论了压力、ScCO₂释放速率以及水与 ScCO₂的体积比对所得胶束载药效率（EE）的影响。所得二阶多项式方程可成功预测载药胶束的药物 EE。在压力为 12.27 MPa、释放速率为 10 L min 和水与 ScCO₂的体积比为 3.67:1 的最佳条件下，EE 可达到 70.1%。所制备的胶束具有较窄的粒径分布和相对规则的球形。药物释放研究表明，紫杉醇从胶束中的释放是缓慢且持续的。
