强迫症中的无创脑刺激
Noninvasive brain stimulation in obsessive-compulsive disorder.
作者信息
Shivakumar Venkataram, Dinakaran Damodharan, Narayanaswamy Janardhanan C, Venkatasubramanian Ganesan
机构信息
Department of Psychiatry, WISER Neuromodulation Program, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Department of Psychiatry, OCD Clinic, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
出版信息
Indian J Psychiatry. 2019 Jan;61(Suppl 1):S66-S76. doi: 10.4103/psychiatry.IndianJPsychiatry_522_18.
Abstract
Obsessive-compulsive disorder (OCD) is a complex neuropsychiatric disorder with a chronic course, contributing to significant socio-occupational dysfunction. Forty percent of patients remain treatment refractive despite mainstream treatment options such as serotonin-reuptake inhibitors and cognitive behavior therapy. Noninvasive brain stimulation approaches such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have piqued interest as add-on treatment options in OCD. This review focuses on summarizing the TMS and tDCS studies in OCD with respect to their study design and stimulation parameters and key findings. We also briefly discuss the limitations and future directions noninvasive brain stimulation in OCD.
摘要
强迫症（OCD）是一种病程慢性的复杂神经精神障碍，会导致严重的社会职业功能障碍。尽管有5-羟色胺再摄取抑制剂和认知行为疗法等主流治疗方案，但仍有40%的患者治疗无效。经颅磁刺激（TMS）和经颅直流电刺激（tDCS）等非侵入性脑刺激方法作为强迫症的附加治疗方案引起了人们的兴趣。本综述重点总结了强迫症中TMS和tDCS研究的研究设计、刺激参数和主要发现。我们还简要讨论了强迫症中非侵入性脑刺激的局限性和未来方向。
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