Hwang Ki-Tae, Ju Young Wook, Kim Young A, Kim Jongjin, Oh Sohee, Jung Jiwoong, Chai Young Jun, Choi In Sil, Oh So Won
Department of Surgery, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, Korea.
Department of Surgery, Seoul National University Hospital, Seoul, Korea.
Ann Surg Treat Res. 2019 Feb;96(2):58-69. doi: 10.4174/astr.2019.96.2.58. Epub 2018 Jan 30.
To investigate the prognostic influence of Korean public medical insurance system on breast cancer patients.
Data of 1,068 patients with primary invasive breast cancer were analyzed. Korean public medical insurance status was classified into 2 groups: National Health Insurance and Medical Aid. Kaplan-Meier estimator and Cox proportional hazards model were used for survival analysis.
The Medical Aid group showed worse prognoses compared to the National Health Insurance group both in overall survival (P = 0.001) and recurrence-free survival (P = 0.006). The Medical Aid group showed higher proportion of patients with tumor size > 2 cm (P = 0.022), more advanced stage (P = 0.039), age > 50 years (P = 0.003), and low education level (P = 0.003). The Medical Aid group showed higher proportion of patients who received mastectomy (P < 0.001) and those who received no radiation therapy (P = 0.013). The Medical Aid group showed a higher rate of distant recurrence (P = 0.014) and worse prognosis for the triple negative subtype (P = 0.006). Medical insurance status was a significant independent prognostic factor in both univariate analysis and multivariate analysis.
The Medical Aid group had worse prognosis compared to the National Health Insurance group. Medical insurance status was a strong independent prognostic factor in breast cancer. Unfavorable clinicopathologic features could explain the worse prognosis for the Medical Aid group. Careful consideration should be given to medical insurance status as one of important prognostic factors for breast cancer patients.
探讨韩国公共医疗保险制度对乳腺癌患者预后的影响。
分析1068例原发性浸润性乳腺癌患者的数据。韩国公共医疗保险状况分为两组:国民健康保险和医疗救助。采用Kaplan-Meier估计法和Cox比例风险模型进行生存分析。
在总生存期(P = 0.001)和无复发生存期(P = 0.006)方面,医疗救助组的预后均比国民健康保险组差。医疗救助组肿瘤大小>2 cm的患者比例更高(P = 0.022),分期更晚(P = 0.039),年龄>50岁(P = 0.003),教育水平低(P = 0.003)。医疗救助组接受乳房切除术的患者比例更高(P < 0.001),未接受放射治疗的患者比例更高(P = 0.013)。医疗救助组远处复发率更高(P = 0.014),三阴性亚型的预后更差(P = 0.006)。在单因素分析和多因素分析中,医疗保险状况都是一个显著的独立预后因素。
与国民健康保险组相比,医疗救助组的预后更差。医疗保险状况是乳腺癌的一个强有力的独立预后因素。不良的临床病理特征可以解释医疗救助组预后较差的原因。应将医疗保险状况作为乳腺癌患者重要的预后因素之一予以认真考虑。